생명과학회지 (Journal of Life Science)

  • 제16권1호
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  • Pages.156-161
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  • 2006
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
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감송향 정유성분의 흡입 및 경구투여시의 중추신켱 억제효과

Inhibitory Effects of the Essential Oil from Nardostachys intamansi on Central Nervous System after Inhalation and Oral Administration

  • 구병수 (동국대학교 한의과대학 신경정신과) ;
  • 김대근 (동국대학교 한의과대학 신경정신과) ;
  • 최정현 (동국대학교 자연과학대학 생명공학과) ;
  • 이동웅 (동국대학교 자연과학대학 생명공학과)
  • Koo Byung-Soo (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Kim Dae-kun (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University) ;
  • Choi Jung-Hyun (Department of Biotechnology, College of Natural Science, Dongguk University) ;
  • Lee Dong-Ung (Department of Biotechnology, College of Natural Science, Dongguk University)
  • Published : 2006.02.01
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Abstract

The essential oil of Nardostachys jatamansi (Valerianaceae), which has been used for a long time in aroma therapy, was investigated after inhalation or oral administration for its analgesic effect, anticonvulsant action, hypnotic effect and in vitro inhibitory activity on monoamine oxidase. This fragrance oil showed a significant analgesic effect in the phenylquinone-induced .writhing test, suppressed the convulsion induced by pentylenetetrazole and lengthened the pentobarbital-induced sleeping time in a time-dependent manner after fragrance inhalation or dose-independently by oral administration. Its inhibitory activity on monoamine oxidase was remarkable, showing $49.4\%$ inhibition at a concentration of 5.0 mg/ml. Six new terpenes with seven known compounds were detected by our GC-MS analytical conditions used. As a result, the essential oil fragrance of Nardostachys jatamansi would be clinically useful for a sedative by either inhalation or oral administration.

Keywords

References

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