Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Biotransformation of Ginseng to Compound K by Aspergillus oryzae

Aspergillus oryzae를 이용한 수삼으로부터 compound K로의 생물전환

  • Kim Bo-Hye (Department of Microbiology and Immunology, College of Medicine, Pusan National, University) ;
  • Kang Ju-Hyung (Department of Microbiology and Immunology, College of Medicine, Pusan National, University) ;
  • Lee Sun-Yi (Department of Microbiology and Immunology, College of Medicine, Pusan National, University) ;
  • Cho Hyo-Jin (Department of Microbiology and Immunology, College of Medicine, Pusan National, University) ;
  • Kim Yeong-Jin (Department of Microbiology and Immunology, College of Medicine, Pusan National, University) ;
  • Kim Yun Jin (Department of Family Medicine, College of Medicine, Pusan National University) ;
  • Ahn Soon-Cheol (Department of Microbiology and Immunology, College of Medicine, Pusan National, University)
  • 김보혜 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 강주형 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 이선이 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 조효진 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 김영진 (부산대학교 의과대학 미생물학 및 면역학 교실) ;
  • 김윤진 (부산대학교 의과대학 가정의학과) ;
  • 안순철 (부산대학교 의과대학 미생물학 및 면역학 교실)
  • Published : 2006.02.01
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Abstract

Ginseng was fermented by Aspergillus oryzae to search metabolites on the basis of increased biological activity and modified structure. From this research, two biotransformed compounds (WC2-2-1 and WC2-2-2) were detected and isolated through several chromatographic techniques. WC2-2-2 was confirmed to biologically active compound K by TLC, HPLC, and mass spectroscopy, while WC2-2-1 was going to be identified until now. In biological activity, both WG2-2-1 and WG2-2-2 exhibit the cytotoxicity on PC-3 cells, but WG2-2-2 was more active than WG2-2-1. It is supposed that WG2-2-1 is an intermediate metabolite transforming to final WG2-2-2, compound K.

Keywords

References

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