Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effect of Radish on Inflammatory Reaction in Human Epithelial Gastric Cell

사람 위 상피세포의 염증반응에 대한 무의 효과

  • Shon, Yun-Hee (Department of Pharmacology, College of Medicine and Intractable Disease Research Center) ;
  • Chung, Yoo-Sun (Department of Internal Medicine, College of Medicine Dongguk University) ;
  • Suh, Jeong-Ill (Department of Internal Medicine, College of Medicine Dongguk University) ;
  • Park, In-Kyung (Department of Pharmacology, College of Medicine and Intractable Disease Research Center) ;
  • Nam, Kyung-Soo (Department of Pharmacology, College of Medicine and Intractable Disease Research Center)
  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소) ;
  • 정유선 (동국대학교 의과대학 내과학교실) ;
  • 서정일 (동국대학교 의과대학 내과학교실) ;
  • 박인경 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소)
  • Published : 2006.02.01
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Abstract

The effects of Korean and Japanese radishes on inflammatory reaction that involves arachidonic acid cascades were investigated in human epithelial gastric cell. The activities of type I (porcine pancreas) and type II (Crotalus atrox) phospholipase $A_2(PLA_2$) were inhibited by radish. Cyclooxygenase-2 (COX-2) activity was significantly suppressed by radish (p<0.05, p<0.01 and p<0.005). The nitric oxide production was also inhibited by radish. The Korean radish was more effective in inhibition of $PLA_2$ and COX-2 activities and nitric oxide production than Japanease radish. These results indicate that radish has a protective effect on gastric epithelial cell inflammation by suppressing the activities of $PLA_2$ and COX-2 activities and nitric oxide production from gastric epithelial cell.

Keywords

References

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