Crystal Form of Cephradine

  • Published : 2006.02.01

Abstract

Four crystal forms of cephradine were isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. The dissolution patterns of four crystal forms of cephradine were studied in water at $37{\pm}0.5^{\circ}C$, 90 rpm for 120 min. The amount dissolved at 120 min was highest for Form 1 ($100\%$), followed by Form 3 ($98.9\%$), Form 4 ($77.83\%$), and Form 2 ($75.55\%$). After storage for two months at $0\%$ RH (silica gel, $20^{\circ}C$), $52\%$ RH (saturated solution of $Na_{2}Cr_{2}O_{7}{\cdot}2H_{2}O/20^{\circ}C$), and $95\%$ RH (saturated solution of $Na_{2}HPO_{4}/20^{\circ}C$), none of the crystal forms showed transformation.

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References

  1. Giron, D., Thermal analysis and calorimetric methods in the characterization of polymorphs and solvates. Thermochim. Acta, 248, 1-59 (1995) https://doi.org/10.1016/0040-6031(94)01953-E
  2. Grunenberg, A., Polymorphie und thermische analyse pharmazeutischer Wirkstoffe. Pharmazie in unserer Zeit, 26, 224- 231 (1997) https://doi.org/10.1002/pauz.19970260506
  3. Haleblian, J. K., Characterization of habits and crystalline modification of solids and their pharmaceutical applications. J. Pharm. Sci., 64, 1269-1288 (1975) https://doi.org/10.1002/jps.2600640805
  4. Haleblian, J. K. and McCrone, W. C., Pharmaceutical applications of polymorphism. J. Pharm. Sci., 58, 911-929 (1969) https://doi.org/10.1002/jps.2600580802
  5. Higuchi, W.I., Lau, P. K., Higuchi, T., and Shell, J. W., Polymorphism and drug availability, solubility relations in the methylprednisolone system. J. Pharm. Sci., 52, 150-153 (1963) https://doi.org/10.1002/jps.2600520210
  6. Huttenrauch, R., Fundamentals of Pharmaceutics. Acta Pharm. Technol., 34, 1-10 (1988)
  7. Kuhnert-Brandstatter, M., Polymorphie von Arzneistoffen und ihre Bedeutung in der pharmazeutischen Technologie. Informationsdienst A.P.V., 19, 73-90 (1973)
  8. Kuhnert-Brandstätter, M. and Lehner, G., Differentialthermoanalyse und IR-spektroskopische untersucungen von arzneistoffen, die als hydrate vorliegen. Sci. Pharm., 52, 267- 279 (1984)
  9. Shefter, E. and Higuchi, T., Dissolution behavior of crystalline solvated and nonsolvated forms of some pharmaceuticals. J. Pharm. Sci., 52, 781-791 (1963) https://doi.org/10.1002/jps.2600520815
  10. Sohn, Y. T., Effect of crystal form on bioavailability. J. Kor. Pharm. Sci., 34, 443-452 (2004)
  11. Sohn, Y. T., Rhee, J. K., and Im, W. B., Polymorphism of Clarithromycin. Arch. Pharm. Res., 23, 381-384 (2000) https://doi.org/10.1007/BF02975451