Cytotoxic Constituents from Solanum Lyratum

  • Sun Li-Xin (College of Pharmacy, Shenyang Pharmaceutical University) ;
  • Fu Wen-wei (College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University) ;
  • Ren Jing (College of Pharmacy, Shenyang Pharmaceutical University) ;
  • Xu Liang (The Analysis and Testing Center, Inner Mongolia University for Nationalities) ;
  • Bi Kai-Shun (College of Pharmacy, Shenyang Pharmaceutical University) ;
  • Wang Min-Wei (College of Pharmacy, Shenyang Pharmaceutical University)
  • Published : 2006.02.01

Abstract

Activity-guided fractionation of the ethanol extract of the whole plant from Solanum lyratum resulted in the isolation of a new pregnane derivative glycoside, 16-dehydropregnenolone 3-O-${\alpha}$-L-rhamnopyranosyl-($1{\to}2$)-${\beta}$-D-glucopyranosid uronic acid (2), as well as other six known compounds: 16-dehydropregnenolone (1), allopregenolone (3), protocatechuic acid (4), vanillic acid (5), caffeic acid (6), and scopoletin (7). The structures of the isolated compounds were elucidated on the basis of their spectral data and chemical evidences. Compounds 1, 3, 4 were isolated for the first time from this plant. Cytotoxic activities of the isolated compounds were evaluated. Compound 1 exhibited significant cytotoxic activity against A375-S2, HeLa, SGC-7901, and Bel-7402 with $IC_{50}$ values of $13.1{\pm}0.9,\;21.5{\pm}1.0,\;40.2{\pm}0.7$, and $49.8{\pm}1.2\;{\mu}g/mL$, respectively.

Keywords

References

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