Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Close Relationship Between SARS-Coronavirus and Group 2 Coronavirus

  • Kim, Ok-Ju (Division of Life Sciences Chungbuk National University) ;
  • Lee, Dong-Hun (Division of Life Sciences Chungbuk National University, Research Institute for Biotechnology, Chungbuk National University) ;
  • Lee, Chan-Hee (Division of Life Sciences Chungbuk National University, Research Institute for Biotechnology, Chungbuk National University)
  • Published : 2006.02.01
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Abstract

The sudden appearance and potential lethality of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) in humans has resulted in a focusing of new attention on the determination of both its origins and evolution. The relationship existing between SARS-CoV and other groups of coronaviruses was determined via analyses of phylogenetic trees and comparative genomic analyses of the coronavirus genes: polymerase (Orflab), spike (S), envelope (E), membrane (M) and nucleocapsid (N). Although the coronaviruses are traditionally classed into 3 groups, with SARS-CoV forming a $4^{th}$ group, the phylogenetic position and origins of SARS-CoV remain a matter of some controversy. Thus, we conducted extensive phylogeneitc analyses of the genes common to all coronavirus groups, using the Neighbor-joining, Maximum-likelihood, and Bayesian methods. Our data evidenced largely identical topology for all of the obtained phylogenetic trees, thus supporting the hypothesis that the relationship existing between SARS-CoV and group 2 coronavirus is a monophyletic one. Additional comparative genomic studies, including sequence similarity and protein secondary structure analyses, suggested that SARS-Co V may bear a closer relationship with group 2 than with the other coronavirus groups. Although our data strongly suggest that group 2 coronaviruses are most closely related with SARS-CoV, further and more detailed analyses may provide us with an increased amount of information regarding the origins and evolution of the coronaviruses, most notably SARS-CoV.

Keywords

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