납 취급 근로자의 Monte-Carlo simulation을 이용한 노출 및 건강위해성평가

Exposure and Health Risk Assessment of Lead Workers using Monte-Carlo Simulation

  • 염정호 (전북대학교 의과대학 예방의학교실) ;
  • 권근상 (전북대학교 의과대학 예방의학교실) ;
  • 이주형 (전북대학교 의과대학 예방의학교실) ;
  • 정주원 (전북대학교 의과대학 예방의학교실)
  • Yeom, Jung Ho (Department of Preventive Medicine and Public Health, School of Medicine Chonbuk National University) ;
  • Gwon, Keun Sang (Department of Preventive Medicine and Public Health, School of Medicine Chonbuk National University) ;
  • Lee, Ju-Hyoung (Department of Preventive Medicine and Public Health, School of Medicine Chonbuk National University) ;
  • Jeong, Joo-Won (Department of Preventive Medicine and Public Health, School of Medicine Chonbuk National University)
  • 투고 : 2005.11.01
  • 심사 : 2006.05.01
  • 발행 : 2006.06.30

초록

Objective : This study was conducted to quantify chronic lead exposure from various media(ie. working environment, food, ambient air), and to certify the usefulness of exposure assessment using Monte-Carlo simulation in the fields of occupational health. Methods : Data were obtained from Korean Industrial Health Association, Korea Food and Drug Administration, and the Ministry of Environment. Then lead worker's exposure was estimated indirectly from various media and parameters (ie. volume inhaled, body weight, dietary intake, etc.). Uncertainty was analyzed by Monte Carlo simulation with Crystal Ball software. Exposure doses and hazard indices were simulated with various hypothetical scenarios including weekly working hours and respiratory protective equipment. Results : Without respiratory protective equipment, the total exposure dose per kilogram of body weight of lead workers was estimated as $5.45{\times}10^{-3}mg/kg/day$, and hazard index was estimated as 2.26, and exposure contributions were calculated as follows : working environment(82.42 %); foods(17.57 %); and ambient air(0.01 %). But, if working condition has changed - reduction of working hours and using respiratory protective equipment, the total exposure dose per kilogram of body weight was estimated between $1.34{\times}10^{-3}-1.49{\times}10^{-3}mg/kg/day$, and hazard index was estimated between 0.56 - 0.62. Conclusions : This study suggested that occurrence of hazardous impact(ie. increased blood pressure) through lifetime lead exposure would be expected, and that the Monte-Carlo simulation was useful for the fields of occupational health.

키워드

과제정보

연구 과제 주관 기관 : 전북대학교

참고문헌

  1. 국립기술품질원. 산업제품의 표준치 설정을 위한국민표준 체위 조사 보고서. KRISS-97-114-IR, 1997
  2. 송혜향. 의학, 간호학, 사회과학 연구의 메타분석법. 청문각. 2003
  3. 이서래, 이효민, 허근, 이미경, 한국인을 위한 식품 평균소비량(1990년대) 자료의 최적화. 한국식품위생안전성학회지 2000;15(2):68-78
  4. 이효민, 임철주, 김종욱, 최시내, 윤은경 등. 식품중 납의 위해성 평가. 식품의약품안전청연보 1999;3:60-73
  5. 이효민,임철주,윤은경,김종욱,최시내 등.식품중 카드뮴의 위해성평가. 식품의약품안전청연보 2004;4:67-77
  6. 이효민, 한지연, 윤은경, 김효미, 황인균 등. 식품을 통한 유기인계농약류의 동시노출위해성평가. 한국식품위생안전성학회지 2001:16(1):21-26
  7. 정용, 황만식, 양지연, 조성준. 납의 다경로 노출에 의한 건강 위해성평가 : 우리나라 일부 지역 성인들을 대상으로. 한국환경독성학회지 1999;14(4):203-216
  8. 환경부. http://www.me.go.kr
  9. ACGIH. Documentations of the threshold limit values and biological exposures indices. In : Introduction to the documentations of the chemical substances TLVs. 7th Ed. American Conference of Governmental Industrial Hygienist, Cincinnati, 2001
  10. Bono R, Pignata C, Scursatone E, Rovere R, Natale P et al. Updating about reduction of air and blood lead concentrations in Turin, Italy, following reductions in the lead content of gasoline. Environ Res 1995;70:30-34 https://doi.org/10.1006/enrs.1995.1043
  11. Buchet JP, Lauwerys R, Vandevoorde A, Pycke JM. Oral daily intake of cadmium, lead, manganese, copper, chromium, mercury, calcium, zinc and arsenic in Belgium. A duplicate meal study. Food Chem Toxicol 1983;21:19-24 https://doi.org/10.1016/0278-6915(83)90263-6
  12. Castleman BI, Ziem GE. Corporate influence on threshold limit values. Am J Ind Med 1988;13:531-559 https://doi.org/10.1002/ajim.4700130503
  13. Castorina R, Woodruff TJ. Assessment of potential risk levels associated with U.S. Environmental Protection Agency reference values. Environ Health Perspect 2003;111(10):1318-1325 https://doi.org/10.1289/ehp.6185
  14. Castorina R, Crystal Ball${\circledR}$ 2000 Users Guide. Decisioneering, Inc.;2000. p. 172-180
  15. Faustman EM, Omenn. Risk assessment. In : Klassen CD. Casarett & Doull's Toxicology. 6th ed. McGraw Hill; 2001. p. 83-104
  16. Glorennec P. Analysis and reduction of the uncertainty of the assessment of children's lead exposure around an old mine. Environ Res 2006;100(2):150-158 https://doi.org/10.1016/j.envres.2005.03.007
  17. Grammer LC, Harris KE, Yarnold PR. Effect of respiratory protective devices on development of antibody and occupational asthma to an acid anhydride. Chest 2002;121:1317-1322 https://doi.org/10.1378/chest.121.4.1317
  18. Helton JC, Shiver AW. A Monte-Carlo procedure for the construction of complementary cumulative distribution functions for radioactive waste disposal. Risk Anal 1996;16(2):43-45 https://doi.org/10.1111/j.1539-6924.1996.tb01435.x
  19. Hewett P. Mean testing: I. Advantages and disadvantages. Appl Occup Environ Hyg 1997;12(5):339-346 https://doi.org/10.1080/1047322X.1997.10389516
  20. ICRP. International Commission on Radiological protection. Report of the task group on reference man. New York: Pergammon Press. 1981
  21. Ikeda M, Zhang ZW, Shimbo S, Watanabe T, Nakatsuka H et al. Exposure of women in general populations to lead via food and air in east and southeast Asia. Am J Ind Med 2000a;38:271-280 https://doi.org/10.1002/1097-0274(200009)38:3<271::AID-AJIM5>3.0.CO;2-3
  22. Ikeda M, Zhang ZW, Shimbo S, Watanabe T, Nakatsuka H et al. Urban population exposure to lead and cadmium in east and south-east Asia. Sci Total Environ 2000b;249:373-384 https://doi.org/10.1016/S0048-9697(99)00527-6
  23. IPCS. Environmental health criteria 85. Lead. environmental aspects. International Programme on Chemical Safety, World Health Organization, Geneva, 1989
  24. IPCS. Environmental health criteria 165, Inorganic lead. International Programme on Chemical Safety, World Health Organization, Geneva, 1995
  25. JECFA, Summary and Conclusions 53rd Meeting. World Health Organisation, Joint FAO/OMS Expert Comitee on Food Additives, Geneva. 1999
  26. Kofi AD. Risk assessment in environmental management. A guide for managing chemical contamination problems. West Sussex : John Wiley & Sons Ltd.; 1998. p. 181-192
  27. Kotseva K. Occupational exposure to low conc of carbon disulfide as a risk factor for hypercholesterolaemia. Int Arch Occup Environ Health 2001;74:38-42 https://doi.org/10.1007/s004200000186
  28. Li H, Wang ML, Seixas N, Duchtman A, Lee Petsonk E. Respiratory protection : Associated factors and effectiveness of respirator ode among underground coal miners. Am J Ind Med 2002;42:55-62 https://doi.org/10.1002/ajim.10079
  29. Martyny J, Glazer CS, Newman LS. Respiratory protection. N Engl J Med 2002;347(10) :824-830 https://doi.org/10.1056/NEJMra012670
  30. Moon CS, Zhang ZW, Shimbo S, Watanabe T, Moon DH et al. Dietary intake of cadmium and lead among general population in Korea. Environ Research 1995;71:46-54 https://doi.org/10.1006/enrs.1995.1066
  31. Moon CS, Paik JM, Choi CS, Kim DH, Ikeda M. Lead and cadmium levels in daily foods, blood and urine in children and their mothers in Korea. Int Arch Occup Environ Health 2003;76:282-288
  32. Muller-Wening D, Repp H. Investigation od the protective value of breathing masks in farmer's lung using an inhalation provocation test. Chest 1989;95:100-105 https://doi.org/10.1378/chest.95.1.100
  33. Mukesh Shamara, Mayank Maheshwri, Morisawa S. Dietary and inhalation intake of lead and estimation of blood lead levels in adults and children in Kanpur, India. Risk Anal 2005;25(6):1573-1588 https://doi.org/10.1111/j.1539-6924.2005.00683.x
  34. Nicas M, Hubbard A. A risk analysis approach to selecting respiratory protection against airborne pathogens used for bioterrism. Am I Ind Hyg Assoc 2003;64(1):95-101 https://doi.org/10.1080/15428110308984797
  35. Nicas M, Neuhaus J. variability in respiratory protection and the assigned protection factor. J Occup Environ Hyg 2004;1(2):99-109 https://doi.org/10.1080/15459620490275821
  36. NIOSH. NIOSH guide to industrial respiratory protection. National Institute for Occupational Safety and Health, Cincinnati, September, 1987. DHHS Publication No. 87-116 (URL : http://www.cdc.gov/niosh/ 87-116.html)
  37. Page NP. Human health risk assessment. In : Cockerham LG, Shane BS. Basic Environmental Toxicology. Florida : CRC Press Inc.; 1994. p. 563-565
  38. Price PS, Su SH, Harrington JR. Uncertainty and variation in Indirect exposure to Tetrachlorodibenzo-p-dioxin from a beef consumption pathways. Risk Anal 1996;16(2):43-46 https://doi.org/10.1111/j.1539-6924.1996.tb01435.x
  39. Rappapaport SM. 1993. Threshold limit values, permissible exposure limits, and feasibility : The bases for exposure limits in the United States. Am J Ind Med 1993;23:683-694 https://doi.org/10.1002/ajim.4700230502
  40. Roach. SA, Rappaport SM. But they are not thresholds: A critical analysis of the documentation of threshold limit values. Am J Ind Med 1990;17:727-753 https://doi.org/10.1002/ajim.4700170607
  41. Ruden C. Scrutinizing ACGIH Risk Assessments : The trichloroethylene case. Am J Ind Med 2003;44:207.213 https://doi.org/10.1002/ajim.10252
  42. Sannolo N, Carell G. De Lorenzo, Castellino N. Sources, properties, and fate of airborne lead. In : Castellino N, Castellino P, Sannolo N. Inorganic lead exposure. Metabolism and intoxication. Florida : CRC Press Inc.; 1995. p. 60
  43. Taivainen AI, Tukiainen HO, Terho EO, Husman KR. Powered dust respirator helmets in the prevention of occupational asthma among farmers. Scand J work Environ Health 1998;24(6):503-507 https://doi.org/10.5271/sjweh.375
  44. US EPA. Risk assessment guidance for superfund. Volume I. Human health evaluation manual, PartA. Office of Emergency and Remedial Response, Washington DC, December 1989, EPA/540/1-89/002. Available from: http://www.epa.gov/ oerrpage/superfund/programs/risk/index. htm
  45. US EPA. Guidelines for exposure assessment. Exposure Assessment Group, Office of Health and Environmental Assessment, Washington DC, May 29, 1992, EPA/600/Z- 92/001. Available from: URL:http://www.epa.gov/ nceawww1/raf/pdfs/exposure.pdfs
  46. US EPA. The exposure factors handbook. Office of Research and Development, National Center for Environmental Assessment, Washington DC, 1997, EPA/600/P-95/002FaUS. Available from: URL:http://www.epa.gov/ncea/pdfs/efh
  47. US EPA. Guiding Principles for Monte Carlo Analysis. EPA/630/R-97/001March 1997. Available from: URL:http:// www.epa.gov/ncea/raf.montecar.pdf
  48. US EPA. Guidence for submission of probabilistic exposure assessments to the office of pesticide program's health effects division. Office of Pesticide Programs, Washington DC, December 1998
  49. US EPA. Risk Assessment Guidance for Superfund, Volume 3 Part A: Process for Conducting Probabilistic Risk Assessment (RAGS 3A) (DRAFT) Washington DC, 1999. Available from: URL:http://www.epa.gov/oswer/riskassessment/rags3adt/pdf/ch apters.pdf
  50. US EPA. A Review of the reference dose and reference concentration process. Risk Assessment Forum, Washington DC, December 2002, EPA/630/P-02/002E. Available from: URL:http:// cfpub.epa.gov/ncea/cfm/recordisplay.cfm? deid=55365
  51. US EPA. Integrated Risk for Information System. Office of Research and Development, National Center for Environmental Assessment, Washington DC, 2003. Available from: URL:http:// www.epa.gov/iris
  52. Vose D. Risk analysis. A quantitative guide. West Sussex : John Wiley & Sons Ltd.; 2000. p. 17
  53. Whaley DA, Attfield MD, Bedillion EJ, Walter KM, Quilong YI. Regression method to estimate provisional TLV/WEELequivalents for non-carcinogens. Ann occup Hyg 2000;44(5):361-374 https://doi.org/10.1016/S0003-4878(99)00108-8
  54. Wu MT. Assessment of the effectiveness of respirator usage in Coke oven workers. Am J Ind Hyg Assoc 2001;63(1):72-75
  55. Ziem GE, Castleman BI. Threshold limit values : Historical perspectives and current practice. J Occup Med 1989;31:910-918 https://doi.org/10.1097/00043764-198911000-00014