References
- Younis JS, Ohel G, Brenner B, Ben-Ami M. Familial thrombophilia - the scientific rationale for thrombophylaxis in recurrent pregnancy loss- Hum Reprod 1997; 12: 1389-90
- Raziel A, Kormberg Y, Fridler S, Schachter M, Sela BA, Ron-El R. Hypercoagulable thrombophilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss. Am J Reprod Immunol 2001; 45: 65-71
- Yamada H, Kato EH, Kobashi G, Ebina Y, Shimada S, Sakuragi N, Fujimoto S. Recurrent pregnancy loss: Etiology of thrombophilia. Semin Thromb Hemost 2001;27: 121-9 https://doi.org/10.1055/s-2001-14070
- Nelen WLMD, Blom HJ, Steegers EAP, den Heijer M, Eskes TKAB. Hyperhomocysteinemia and recurrent early pregnancy loss: a meta analysis. Fertil Steril 2000; 74: 1196-99
- McCully KS. Chemical pathology of homocysteine. Ann Clin Lab Sci 1994; 24: 27-59
- Chango A, Boisson F, Barbe F, Quilliot D, Droesch S, Pfister M, et al. The effect of 677C->T and 1298 A ->C mutations on plasma homocysteine and 5, 10-methylenetetrahydrofolate reductase activity in healthy subjects. Br J Nutr 2000; 83: 593-6
- Loscalzo J. The oxidant stress of hyperhomocysteinemia. J Clin Invest 1996; 98: 5-7
- Fodinger M, Wagner OF, Horl WH, Sunder-Plassmann G. Recent insights into the molecular genetics of the homocysteine metabolism. Kidney Int 59 Suppl 2001;78: S238-42
- Jakubowski H, Zhang L, Bardeguez A, Aviv A. Homocysteine thiolactone and proteine homocysteinylation in human endothelial cells: implications for athero-sclerosis. Cir Res 2000; 87: 45-57
- Matsuo K, Suzuki R, Hamajima N, Ogura M, Kagami Y, Taji H, et al. Association between polymorphisms of folate and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 2001; 97: 3205-9
- Wouters MGAJ, Boers GHJ, Blom HJ, Trijbels FJM, Tomas CMG, Borm GF. Hyperhomocysteinaemia: a risk factorin women with unexplained recurrent early pregnancy loss. Fertil Steril 1993; 60: 820-5
- Quere I, Bellet H, Hofet M, Janbon C, Mares P, Gris JC. A women with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages. Fertil Steril 1998; 68: 152-4
- Isotalo PA, Wells GA, Donnelly JG. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet 2000; 67: 986-90
- Zetterberg H, Regland B, Palmer M, Ricksten A, Palmqvist L, Rymo L, et al., Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos. Eur J Hum Genet 2002; 10: 113-8
- Zetterberg H, Zafiropoulos A, Spandidos DA, Rymo L, Blennow K. Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion. Hum Reprod 2003; 18: 1948-50
- Kim NK, Nam YS, Lee S, Kim SH, Shin SJ, Chang SW, et al. Polymorphisms of 5,10-Methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene in recurrent spontaneous abortion. Kor J Fertil Steril 2002; 29: 215-22
- Horie N, Aiba H, Oguro K, Hojo H, Takeishi K. Functional analysis and DNA polymorphism of the tandemly repeted sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 1995; 20: 191-7
- Choi YK, Kang MS, Kim NK, Kim SH, Choi DH, Ahn MO, et al. Contribution of thymidylate synthase enhancer region (TSER) polymorphism to total plasma homocysteine levels in Korean patients with recurrent spontaneous abortion. Kor J Fertil Steril 2004; 31: 183-90
- Van der Molen EF, Arends GE, Nelen EL, van der Put NJ, Heil SG, Eskes TK, Blom HJ. A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy. Am J Obstet Gynecol 2000; 182: 1258-63
- Kluijtmans LA, Boers GH, Verbruggen B, Trijbels FJ, Novakova IR, Blom HJ. Homozygous cystathionine beta-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis. Blood 1998; 91: 2015-8
- Eskes TK. Homocysteine and human reproduction. Clin Exp Obstet Gynecol 2000; 27: 157-67
- Yates Z, Lucock M. Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event. Mol Genet Metab 2003; 79: 201-13
- Nelen WL, Steegers EA, Eskes TK, Blom HJ. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 1997; 350: 861
- Holmes ZR, Regan L, Chilcott I, Cohen H. The C677T MTHFR gene mutation is not predictive of risk for recurrent fetal loss. British J Haematol 1999; 105: 98-101
- Lissak A, Sharon A, Fruchter 0, Kassel A, Sanderovitz, Abramovici H. Polymorphism for mutation of cytosine to thymine at location 677 in the methylenetetrahydrofolate reductase gene is associated with recurrent early fetal loss. Am J Obstet Gynecol 1999; 181: 126-30
- Grandone E. Methylenetetrahydrofolate reductase (MTHFR) 677T ->C mutation and unexplained early pregnancy loss. Thromb Haemost 1998; 79: 1056-7
- Murphy RP, Donoghue C, Nallen RJ, D'Mello M, Regan C, Whitehead AS, et al. Prospective evaluation of the risk conferred by factor V Leiden and thermolabile methylenetetrahydrofolate reductase polymorphism in pregnancy. Artherioscler Thromb Vasc Biol 1999; 20: 266-70
- Foka ZJ, Lambropoulos AF, Saravelos H, Karas GB, Karavida A, Agorastos T, et al. Factor V leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. Hum Reprod 2000; 15: 458-62
- Kutteh WH, Park VM, Deither SR. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil Steril 1999; 71: 1048-53
- Brenner B, Sarig G, Weiner Z, Younis J, Blumenfeld Z, Lanir N. Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb Haemost 1999; 82: 6-9
- Van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural tube defects- Am J Hum Genet 1998; 62: 1044-51
- Gebhardt GS, Scholtz CL, Hillermann R, Odendaal HJ. Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placenta but not with intrauterine growth restriction. Eur J Obstet Gynecol Reprod Biol 2001; 97: 174-7
- Zetterberg H. Methylenetetrahydrofolate and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications. Reprod Biol Endocrinol 2004; 2: 7