References
- Albertoni, M., Shaw, P. H., Nozaki, M., Godard, S., Tenan, M., Hamou, M. F., Fairlie, D. W., Breit, S. N., Paralkar, V. M., de Tribolet, N., Van Meir, E. G. and Hegi, M. E. (2002) Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1. Oncogene 21, 4212-4219 https://doi.org/10.1038/sj.onc.1205610
- Baek, S. J. and Eling, T. E. (2006a) Changes in gene expression contribute to cancer prevention by COX inhibitors. Prog. Lipid Res. 45, 1-16 https://doi.org/10.1016/j.plipres.2005.10.001
- Baek, S. J., Horowitz, J. M. and Eling, T. E. (2001a) Molecular cloning and characterization of human nonsteroidal antiinflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3. J. Biol. Chem. 276, 33384-33392 https://doi.org/10.1074/jbc.M101814200
- Baek, S. J., Kim, J. S., Moore, S. M., Lee, S. H., Martinez, J. and Eling, T. E. (2005) Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol. Pharmacol. 67, 356-364 https://doi.org/10.1124/mol.104.005108
- Baek, S. J., Kim, J. S., Nixon, J. B., DiAugustine, R. P. and Eling, T. E. (2004) Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J. Biol. Chem. 279, 6883-6892 https://doi.org/10.1074/jbc.M305295200
- Baek, S. J., Kim, K. S., Nixon, J. B., Wilson, L. C. and Eling, T. E. (2001b). Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol. Pharmacol. 59, 901-908 https://doi.org/10.1124/mol.59.4.901
- Baek, S. J., Okazaki, R., Lee, S. H., Martinez, J., Kim, J. S., Yamaguchi, K., Mishina, Y., Martin, D. W., Shoieb, A., McEntee, M. F. and Eling, T. E. (2006b) Nonsteroidal antiinflammatory drug activated gene-1 overexpression in transgenic mice suppresses intestinal neoplasia. Gastroenterology in press
- Baek, S. J., Wilson, L. C. and Eling, T. E. (2002a) Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis 23, 425-432 https://doi.org/10.1093/carcin/23.3.425
- Baek, S. J., Wilson, L. C., Lee, C. H. and Eling, T. E. (2002b) Dual function of nonsteroidal anti-inflammatory drugs (NSAIDs): inhibition of cyclooxygenase and induction of NSAID-activated gene. J. Pharmacol. Exp. Ther. 301, 1126- 1131 https://doi.org/10.1124/jpet.301.3.1126
- Bauskin, A. R., Brown, D. A., Junankar, S., Rasiah, K. K., Eggleton, S., Hunter, M., Liu, T., Smith, D., Kuffner, T., Pankhurst, G. J. et al. (2005) The propeptide mediates formation of stromal stores of PROMIC-1: role in determining prostate cancer outcome. Cancer Res. 65, 2330-2336 https://doi.org/10.1158/0008-5472.CAN-04-3827
- Bauskin, A. R., Zhang, H. P., Fairlie, W. D., He, X. Y., Russell, P. K., Moore, A. G., Brown, D. A., Stanley, K. K. and Breit, S. N. (2000) The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1. Embo J. 19, 2212-2220 https://doi.org/10.1093/emboj/19.10.2212
- Bootcov, M. R., Bauskin, A. R., Valenzuela, S. M., Moore, A. G., Bansal, M., He, X. Y., Zhang, H. P., Donnellan, M., Mahler, S., Pryor, K., Walsh, B. J., Nicholson, R. C., Fairlie, W. D., Por, S. B, Robbins, J. M. and Breit, S. N. (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc. Natl. Acad. Sci. USA 94, 11514-11519 https://doi.org/10.1073/pnas.94.21.11514
- Bottner, M., Suter-Crazzolara, C., Schober, A. and Unsicker, K. (1999) Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophageinhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res 297, 103-110 https://doi.org/10.1007/s004410051337
- Bottone, F. G., Jr., Baek, S. J., Nixon, J. B. and Eling, T. E. (2002) Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. J. Nutr. 132, 773-778 https://doi.org/10.1093/jn/132.4.773
- Brown, D. A., Ward, R. L., Buckhaults, P., Liu, T., Romans, K. E., Hawkins, N. J., Bauskin, A. R., Kinzler, K. W., Vogelstein, B. and Breit, S. N. (2003) MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin. Cancer Res. 9, 2642-2650
- Detmer, K., Steele, T. A., Shoop, M. A. and Dannawi, H. (1999). Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines. Blood Cells Mol. Dis. 25, 310-323 https://doi.org/10.1006/bcmd.1999.0259
- Fairlie, W. D., Russell, P. K., Wu, W. M., Moore, A. G., Zhang, H. P., Brown, P. K., Bauskin, A. R. and Breit, S. N. (2001) Epitope mapping of the transforming growth factor-beta superfamily protein, macrophage inhibitory cytokine-1 (MIC-1): identification of at least five distinct epitope specificities. Biochemistry 40, 65-73 https://doi.org/10.1021/bi001064p
- Fearon, E. R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell 61, 759-767 https://doi.org/10.1016/0092-8674(90)90186-I
- Hayes, V. M., Severi, G., Southey, M. C., Padilla, E. J., English, D. R., Hopper, J. L., Giles, G. G. and Sutherland, R. L. (2006) Macrophage inhibitory cytokine-1 H6D polymorphism, prostate cancer risk, and survival. Cancer Epidemiol. Biomarkers Prev. 15, 1223-1225 https://doi.org/10.1158/1055-9965.EPI-06-0063
- Hsiao, E. C., Koniaris, L. G., Zimmers-Koniaris, T., Sebald, S. M., Huynh, T. V. and Lee, S. J. (2000) Characterization of growthdifferentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol. Cell. Biol. 20, 3742-3751 https://doi.org/10.1128/MCB.20.10.3742-3751.2000
- Karan, D., Chen, S. J., Johansson, S. L., Singh, A. P., Paralkar, V. M., Lin, M. F. and Batra, S. K. (2003) Dysregulated expression of MIC-1/PDF in human prostate tumor cells. Biochem. Biophys. Res. Commun. 305, 598-604 https://doi.org/10.1016/S0006-291X(03)00823-4
- Kim, K. S., Baek, S. J., Flake, G. P., Loftin, C. D., Calvo, B. F. and Eling, T. E. (2002). Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. Gastroenterology 122, 1388-1398 https://doi.org/10.1053/gast.2002.32972
- Kim, K. S., Shin, J. H., Baek, S. J. and Yoon, J. H. (2003) Expression of non-steroidal anti-inflammatory drug-activated gene-1 in human nasal mucosa and cultured nasal epithelial cells: a preliminary investigation. Acta Otolaryngol. 123, 857- 861 https://doi.org/10.1080/00016480310000584b
- Kim, K. S., Yoon, J. H., Kim, J. K., Baek, S. J., Eling, T. E., Lee, W. J., Ryu, J. H., Lee, J. G., Lee, J. H. and Yoo, J. B. (2004) Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal antiinflammatory drug-activated gene. Biochem. Biophys. Res. Commun. 325, 1298-1303 https://doi.org/10.1016/j.bbrc.2004.10.176
- Kinzler, K. W., Nilbert, M. C., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hamilton, S. R., Hedge, P., Markham, A. and et al. (1991) Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251, 1366-1370 https://doi.org/10.1126/science.1848370
- Kinzler, K. W. and Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell 87, 159-170 https://doi.org/10.1016/S0092-8674(00)81333-1
- Lambert, J. R., Kelly, J. A., Shim, M., Huffer, W. E., Nordeen, S. K., Baek, S. J., Eling, T. E. and Lucia, M. S. (2006) Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell. Physiol. 208, 566-574 https://doi.org/10.1002/jcp.20692
- Lawton, L. N., Bonaldo, M. F., Jelenc, P. C., Qiu, L., Baumes, S. A., Marcelino, R. A., Jesus, G. M., Wellington, S., Knowles, J. A., Warburton, D., Brown, S. and Soares, M. B. (1997) Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta. Gene 203, 17-26 https://doi.org/10.1016/S0378-1119(97)00485-X
- Lee, D. H., Yang, Y., Lee, S. J., Kim, K. Y., Koo, T. H., Shin, S. M., Song, K. S., Lee, Y. H., Kim, Y. J., Lee, J. J., Choi, I., Lee, J. H. (2003) Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res. 63, 4648-4655
- Lee, S. H., Kim, J. S., Yamaguchi, K., Eling, T. E. and Baek, S. J. (2005) Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem. Biophys. Res. Commun. 328, 63-69 https://doi.org/10.1016/j.bbrc.2004.12.138
- Lee, S. H., Yamaguchi, K., Kim, J. S., Eling, T. E., Safe, S., Park, Y. and Baek, S. J. (2006) Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis 27, 972-981 https://doi.org/10.1093/carcin/bgi268
- Li, P. X., Wong, J., Ayed, A., Ngo, D., Brade, A. M., Arrowsmith, C., Austin, R. C. and Klamut, H. J. (2000) Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J. Biol. Chem. 275, 20127-20135
- Lindmark, F., Zheng, S. L., Wiklund, F., Bensen, J., Balter, K. A., Chang, B., Hedelin, M., Clark, J., Stattin, P., Meyers, D. A., Adami, H. O, Isaacs, W., Grönberg, H. and Xu, J. (2004) H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer. J. Natl. Cancer Inst. 96, 1248- 1254 https://doi.org/10.1093/jnci/djh227
- Liu, T., Bauskin, A. R., Zaunders, J., Brown, D. A., Pankhurst, S., Russell, P. J. and Breit, S. N. (2003) Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res. 63, 5034-5040
- Martinez, J. M., Sali, T., Okazaki, R., Anna, C., Hollingshead, M., Hose, C., Monks, A., Walker, N. J., Baek, S. J. and Eling, T. E. (2006) Drug-induced expression of nonsteroidal antiinflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharmacol. Exp. Ther. 318, 899-906 https://doi.org/10.1124/jpet.105.100081
- Newman, D., Sakaue, M., Koo, J. S., Kim, K. S., Baek, S. J., Eling, T. and Jetten, A. M. (2003) Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol. Pharmacol. 63, 557-564 https://doi.org/10.1124/mol.63.3.557
- Paralkar, V. M., Vail, A. L., Grasser, W. A., Brown, T. A., Xu, H., Vukicevic, S., Ke, H. Z., Qi, H., Owen, T. A. and Thompson, D. D. (1998) Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J. Biol. Chem. 273, 13760-13767 https://doi.org/10.1074/jbc.273.22.13760
- Shim, M. and Eling, T. E. (2005). Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC- 1 expression in LNCaP prostate carcinoma cells. J. Biol. Chem. 280, 18636-18642 https://doi.org/10.1074/jbc.M414613200
- Tan, M., Wang, Y., Guan, K. and Sun, Y. (2000) PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc. Natl. Acad. Sci. USA 97, 109-114 https://doi.org/10.1073/pnas.97.1.109
- Thomas, R., True, L. D., Lange, P. H. and Vessella, R. L. (2001) Placental bone morphogenetic protein (PLAB) gene expression in normal, pre-malignant and malignant human prostate: relation to tumor development and progression. Int. J. Cancer 93, 47-52
- Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M., Nakamura, Y., White, R., Smits, A. M. and Bos, J. L. (1988) Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319, 525-532 https://doi.org/10.1056/NEJM198809013190901
- Welsh, J. B., Sapinoso, L. M., Su, A. I., Kern, S. G., Wang- Rodriguez, J., Moskaluk, C. A., Frierson, H. F., Jr. and Hampton, G. M. (2001) Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res. 61, 5974-5978
- Wilson, L. C., Baek, S. J., Call, A. and Eling, T. E. (2003) Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. Int. J. Cancer 105, 747-753 https://doi.org/10.1002/ijc.11173
- Yamaguchi, K., Lee, S. H., Eling, T. E. and Baek, S. J. (2004). Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. J. Biol. Chem. 279, 49617-49623 https://doi.org/10.1074/jbc.M408796200
- Yamaguchi, K., Lee, S. H., Eling, T. E. and Baek, S. J. (2006). A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol. Cancer Ther. 5, 1352-1361 https://doi.org/10.1158/1535-7163.MCT-05-0528
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