Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Assessment of Hemodynamic Properties of Trileaflet Polymer Heart Valve Manufactured By Vacuum Forming Process

진공성형을 이용한 삼엽식 고분자 심장판막의 제작과 혈류역학적 성능평가

  • Kim, K.H. (Biomedical Engineering, Brain Korea 21 Project for Biomedical Science College of Medicine, Korea University) ;
  • Hwang, C.M. (Korea Artificial Organ Center, Korea University) ;
  • Jeong, G.S. (Biomedical Engineering, Brain Korea 21 Project for Biomedical Science College of Medicine, Korea University) ;
  • Ahn, C.B. (Biomedical Engineering, Brain Korea 21 Project for Biomedical Science College of Medicine, Korea University) ;
  • Kim, B.S. (Biomedical Engineering, Brain Korea 21 Project for Biomedical Science College of Medicine, Korea University) ;
  • Lee, J.J. (Korea Artificial Organ Center, Korea University) ;
  • Nam, K.W. (Korea Artificial Organ Center, Korea University) ;
  • Sun, K. (Biomedical Engineering, Brain Korea 21 Project for Biomedical Science College of Medicine, Korea University)
  • 김경현 (고려대학교 의과대학 BK21 의용생체공학) ;
  • 황창모 (고려대학교 한국인공장기센터) ;
  • 정기석 (고려대학교 의과대학 BK21 의용생체공학) ;
  • 안치범 (고려대학교 의과대학 BK21 의용생체공학) ;
  • 김범수 (고려대학교 의과대학 BK21 의용생체공학) ;
  • 이정주 (고려대학교 한국인공장기센터) ;
  • 남경원 (고려대학교 한국인공장기센터) ;
  • 선경 (고려대학교 의과대학 BK21 의용생체공학)
  • Published : 2006.12.12
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Abstract

In the artificial heart application, productivity and hemodynamic properties of artificial heart valves are crucial in successiful application to long term in vivo trials. This paper is about manufacture and assessment of trileaflet polymer heart valves using vacuum forming process(VFP). The VFP has many advantages such as reduced fabrication time, reproducibility due to relatively easy and simple process for manufacturing. Prior to VFP of trileaflet polymer heart valves, polyurethane(Pellethane 2363 80AE, Dow Chemical) sheet was prepared by extrusion. The sheets were heated and formed to mold shape by vacuum pressure. The vacuum formed trileaflet polymer heart valves fabrication is composed of two step method, first, leaflet forming and second, conduit forming. This two-step forming process made the leaflet-conduit bonding stable with any organic solvents. Hydrodynamic properties and hemocompatibility of the vacuum formed trileaflet polymer heart valves was compared with sorin bicarbon bileaflet heart valve. The percent effective orifice area of vacuum formed trileaflet polymer heart valves was inferior to bileaflet heart valve, but the increase of plasma free hemoglobin level which reflect blood damage was superior in vacuum formed trileaflet polymer heart valves Vacuum formed trileaflet polymer heart valves has high productivity, and superior hemodynamic property than bileaflet heart valves. Low manufacturing cost and blood compatible trileaflet polymer heart valves shows the advantages of vacuum forming process, and these results give feasibility in in vivo animal trials in near future, and the clinical artificial heart development program.

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References

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