Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Differences between 20s and 40s in Activation of the Parietal and Frontal Areas during Visuospatial Task

공간 과제 수행 시 20대와 40대의 두정엽과 전두엽에서의 활성화 차이

  • You, Ji-Hye (Department of Biomedical Engineering, Konkuk University) ;
  • Hong, Yong-Pyo (Department of Biomedical Engineering, Konkuk University) ;
  • Lee, Hang-Woon (Department of Biomedical Engineering, Konkuk University) ;
  • Lee, Soo-Yeol (Department of Biomedical Engineering, Kyunghee University) ;
  • Chung, Soon-Cheol (Department of Biomedical Engineering, Konkuk University)
  • 유지혜 (건국대학교 의학공학부) ;
  • 홍용표 (건국대학교 의학공학부) ;
  • 이행운 (건국대학교 의학공학부) ;
  • 이수열 (경희대학교 동서의학 대학원) ;
  • 정순철 (건국대학교 의학공학부)
  • Published : 2006.12.12
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study is to examine differences between 20s and 40s in visuospatial performance and brain activation areas using functional Magnetic Resonance Imaging (fMRI). Eight male college students in their twenties ($21.5{\pm}2.3$ years old) and six male adults in their forties ($45.7{\pm}2.6$ years old) who were graduated from college participated in the study. A visuospatial task was presented while brain images were acquired by a 3T fMRI system. Compared to the 20s the 40s showed lower visuospatial performance. There were more activations observed at the parietal and superior frontal areas at 20s compared to 40s. There were more activations observed at the middle frontal and occipital areas at 40s compared to 20s. The results of this study show that the lowering of visuospatial performance with aging was correlated to the decrease of activation area at the parietal lobe and the change of activation area at the frontal lobe.

Keywords

References

  1. P.B. Baltes, U. Lindenberger, 'Emergence of a powerful connection between sensory and cognitive functions across the adult life span,' Psychology and Aging, vol. 12, pp.12-21, 1997 https://doi.org/10.1037/0882-7974.12.1.12
  2. B. Cerf-Ducastel, C. Murphy, 'FMRI brain activation in response to odors is reduced in primary olfactory areas of elderly subjects,' Brain Research, vol. 986, pp.39-53, 2003 https://doi.org/10.1016/S0006-8993(03)03168-8
  3. S.A. Huettel, J.D Singerman, and G. McCarthy, 'The effects of aging upon the hemodynamic response measured by functional MRI,'Neurolmage, vol. 13, pp.161-175, 2001
  4. M. D'Esposito, E. Zarahn, G.K Aguirre, and B. Rypma, 'The effects of normal aging on the coupling of neural activity to the bold hemodynamic response, 'Neurolmage, vol. 10, pp.6-14, 1999 https://doi.org/10.1006/nimg.1999.0444
  5. D.M. Barch, T.S. Braver, and F.W. Sabb, D.C. Noll, 'Anterior cingulate and the monitoring of response conflict: evidence from an fMRI study of overt verb generation,' Cognitive Neuroscience, vol. 12, pp.298-305, 2000 https://doi.org/10.1162/089892900562110
  6. PA Reuter-Lorenz, J. Jonides, and E.E. Smith, A. Hartly, A. Miller, C. Marshuetz, R.A. Koeppe, 'Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET,' Cognitive Neuroscience, vol. 12, pp.174-187, 2000 https://doi.org/10.1162/089892900561814
  7. R. Cabeza, N.D. Anderson, and J.K. Locantore, A.R McIntosh, 'Aging gracefully: compensatory brain activity in high-performing older adults,'Neurolmage, vol. 17, pp.1394-1402, 2002 https://doi.org/10.1006/nimg.2002.1280
  8. J. Persson, C.Y.C. Sylvester, and J.K. Nelson, K.M. Welsh, J. Jonides, P.A. Reuter-Lorenz, 'Selection requirements during verb generation: differential redruitment in older and young adults,'Neurolmage, vol. 23, pp.382-1390, 2004 https://doi.org/10.1016/j.neuroimage.2004.06.012
  9. C.L. Grady, F.LM. Craik, 'Changes in memory processing with age,' Current Opinion in Neurobiology, vol. 10, pp.224-231 ,2000 https://doi.org/10.1016/S0959-4388(00)00073-8
  10. C.L. Grady, 'Functional brain imaging and age-related changes in cognition,' Biological Psychology, vol. 54, pp.259-281, 2000 https://doi.org/10.1016/S0301-0511(00)00059-4
  11. J. Jonides, C. Marshuetz, and E.E. Smith, P.A Reuter-Lorenz, R.A. Koeppe, A. Hartly, 'Age differences in behavior and PET activation reveal differences in interference resolution in verbal working memory,' Cognitive Neuroscience, vol. 12,pp.188-196, 2000 https://doi.org/10.1162/089892900561823
  12. J.M. Logan, A.L. Sanders, and A.Z. Snyder, J.C. Morris, R.L. Buckner, 'Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging,' Neuron, vol. 33, pp.827-840, 2002 https://doi.org/10.1016/S0896-6273(02)00612-8
  13. G.T. Stebbins, M.C. Carrillo, and J. Dorman, C. Dirksen, J.E. Desmond, D.A Turner, D.A Bennett, R.S. Wilson, G. Glover, J.D.E. Gabrieli, 'Aging effects on memory encoding in the frontal lobes,' Psychology and Aging, vol. 17, pp.44-55, 2002 https://doi.org/10.1037/0882-7974.17.1.44
  14. R. West, 'Visual distraction, working memory, and aging,' Memory and Cognition, vol. 27-6, pp.1064-1072, 1999
  15. M.K. Johnson, K.J. Mitchell, and C.L. Raye, E.J. Greene, 'An age related deficit in prefrontal cortical function associated with refreshing information,' Psychological Science, vol. 15-2, pp.127-132,2004
  16. M.P. Milham, K.I. Erickson, and M.T. Banich, A.F. Kramer, A. Webb, T. Wszalek, N.J. Cohen, 'Attentional control in the aging brain: insights from an fMRI study of the stroop task,' Brain and Cognition, vol. 49, pp.277-296, 2002 https://doi.org/10.1006/brcg.2001.1501
  17. T. Tormod, S. Karsten, and H. Asa, N. Jade, E. Lars, H. Kenneth, 'Brain localization of attentional control in different age groups by combining functional and structural MRI,' NeuroImage, vol. 22, pp.912-919, 2004 https://doi.org/10.1016/j.neuroimage.2004.02.015
  18. R.C. Oldfield, 'The assessment and analysis of handedness: the Edinburgh Inventory,' Neuropsychologia, vol. 9, pp.97 -113, 1971 https://doi.org/10.1016/0028-3932(71)90067-4
  19. S.R. Lee, Intelligence test 151-Ga Type (High school students-adults), Seoul, Korea: Jungangjucksung Press, 1982
  20. S.R. Lee, K.R. Kim, Aptitude test 251-Ga (High school students - adults), Seoul, Korea: Jungangjucksung Press, 1985
  21. S.B. Park, GATE (General Aptitude Test Battery): academic, job aptitude test type II (for students of middle schools, high schools and universities, and general public), Seoul, Korea: Jungangjucksung Press, 1985
  22. J. Talairach, P. Tournoux, 'Co-planar stereotaxic atlas of the human brain,' Georg Thieme Verlag, Stuttgart, New York
  23. R.C. Gur, D. Alsop, D. Glahn, R. Petty, C.L, Swanson, J.A. Maldjian, B.I Turetsky, J.A. Detre, J. Gee, R.F. Gur, 'An fMRI study of sex differences in regional activation to a verbal and a spatial task,' Brain and Language, vol. 74, pp.157-170, 2000 https://doi.org/10.1006/brln.2000.2325
  24. G.R. Fink,J.C. Marshall, P.R. Weiss, K. Zilles, 'The neural basis of vertical and horizontal line bisection judgments: an fMRI study of normal volunteers,' Neurolmage, vol. 14-1, pp.59-67, 2001
  25. V.W. Ng, E.T. Bulimore, and G.I. de Zubicaray, A. Cooper, J. Suckling, S.C. Williams, 'Identifying rate-limiting nodes in large-scale cortical networks for visuospatial processing: an illustration using FMRI,' Cognitive Neuroscience, vol. 13-4, pp.538-545,2001
  26. S.C. Chung, G.R. Tack, and B. Lee, G.M. Eom, S.Y. Lee, J.H. Sohn, 'The effect of 30% oxygen on visuospatial performance and brain activation: An fMRI study,' Brain and Cognition, vol. 56,pp.279-285, 2004 https://doi.org/10.1016/j.bandc.2004.07.005