Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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The Effect of Limonene on Skin Permeation and Localization of Ascorbic Acid

  • Lee, Sang-Kil (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Woo, Rye-Seung (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Choi, Sung-Up (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Lee, Jae-Hwi (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University) ;
  • Choi, Young-Wook (Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University)
  • Published : 2006.10.21
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Abstract

Poloxamer-based hydrogel formulation for the topical delivery of ascorbic acid(AsA) was prepared and the effect of limonene on AsA skin permeation and localization was evaluated. In vitro rat skin permeation study, the AsA skin permeation of limonene-containing hydrogel was about 3 to 5 fold higher than control hydrogel. However the amount of permeated AsA was independent to the concentration of limonene. On the other hand the localized amount of AsA after 2 h increased proportion to the content of limonene. The increase in the ratio of localized AsA($Q_L$) to permeated AsA($Q_P$) was attributed to the limonene's ability of making polar pathway within stratum corneum by interacting on lipid domain of the skin and the AsA's hydration effect on the stratum corneum and effect on the protein domain of the skin.

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References

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