Korean Journal of Acupuncture
- Volume 23 Issue 4
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- Pages.169-176
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- 2006
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- 2287-3368(pISSN)
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- 2287-3376(eISSN)
Acupuncture at Liver Meridian Protects the Dopaminergic Neuronal Damage in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's Disease Mouse Model
간경보사(肝經補瀉)가 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine로 유도된 파킨슨병 동물 모델에 미치는 영향
- Kim Seung-Tae (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
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Chae Youn-Byong
(Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
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Kim Yun-Jung
(College of Nursign Science, College of Medicine, Kyunghee University) ;
- Kang Min-Jung (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
-
Jung Mi-Young
(Dept. of Pharmacology, College of Medicine, Kyunghee University) ;
-
Chung Joo-Ho
(Dept. of Pharmacology, College of Medicine, Kyunghee University) ;
-
Hahm Dae-Hyun
(Acupuncture & Meridian Science Research Center(AMSRC), Kyunghee University) ;
- Lee Sang-Jae (Institute of Korea Medicine for Healthy Living) ;
- Lee Hye-Jung (Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University) ;
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Park Hi-Joon
(Dept. of Meridian and Acupuncture, College of Korean Medicine, Kyunghee University)
- 김승태 (경희대학교 한의과대학 경혈학교실) ;
-
채윤병
(경희대학교 한의과대학 경혈학교실) ;
-
김연정
(경희대학교 간호과학대학) ;
- 강민정 (경희대학교 한의과대학 경혈학교실) ;
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정미영
(경희대학교 의과대학 약리학교실) ;
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정주호
(경희대학교 의과대학 약리학교실) ;
-
함대현
(경희대학교 의과대학 침구경락과학연구센터) ;
- 이상재 (한방유연구소) ;
- 이헤정 (경희대학교 한의과대학 경혈학교실) ;
-
박히준
(경희대학교 한의과대학 경혈학교실)
- Published : 2006.12.27
Abstract
Objectives : This study was designed to compare the effects of tonification and sedation methods of Liver Meridian in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mice model. Methods : We injected MPTP (30 mg/kg, i.p.) or saline for 5 consecutive days. Acupuncture treatments were given to the mice with MPTP at LR8 and LR4 to tonify Liver Meridian (Liver+) or LR4 and LR2 to sedate it (Liver-) for 12 day. At the 12th day after first injection, mice were perfused, and then tyrosine hydroxylase (TH)-immunohistochemistry was performed in substantia nigra (SN) of their brains. After counting the number of TH-positive neurons, we compared their numbers among experimental groups. Results : The number of TH-positive neurons of Liver+ group was significantly increased compared to that of MPTP group in the SN. That of Liver-group was also increased more than MPTP group, but not significantly. Conclusions : Tonifying Liver Meridian might be effective therapeutic tools for the neuroprotection in subchronic MPTP-induced mice model.
Keywords
- acupuncture;
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP);
- tonification;
- sedation;
- Liver Meridian