Ectopic Growth Hormone-Secreting Pituitary Adenoma of the Clivus

  • Choi, Jae-Hyung (Departments of Neurosurgery, Brain Tumor Institute, College of Medicine, Dong-A University) ;
  • Park, Mi-Kyoung (Departments of Endocrinology, Brain Tumor Institute, College of Medicine, Dong-A University) ;
  • Choi, Sun-Seob (Departments of Diagnostic Radiology, Brain Tumor Institute, College of Medicine, Dong-A University) ;
  • Kim, Ki-Uk (Departments of Neurosurgery, Brain Tumor Institute, College of Medicine, Dong-A University)
  • Published : 2006.04.30

Abstract

Ectopic pituitary adenoma, occurring outside the sella turcica without any continuity with intrasellar pituitary gland is very rare. So far, less than 90 such cases have been reported in the literature. Regarding to ectopic locations, suprasellar region, sphenoid sinus and clivus have been reported in decending order of frequency. To our best knowledge, growth hormone-secreting ectopic pituitary adenoma in the clivus has never been reported. With the pertinent literature review, we present our unique case with its characteristic magnetic resonance imaging and immunohistochemical features.

Keywords

References

  1. Chan MR, Ziebert M, Maas DL, Chan PS : 'My rings won't fit anymore.' Ectopic growth hormone-secreting tumor. Am Fam Physician 71 : 1766- 1767, 2005
  2. Erdheim J : Uber einen Hypophysen tumor van ungewohnlichem Sitz. Beitr Pathol Anat 46: 223-249, 1909
  3. Gondim JA, Schops M, Ferreira E, Bulcao T, Mota JI, Silveira C : Acromegaly due to an ectopic pituitary adenoma in the sphenoid sinus. Acta Radiol 45 : 689-691, 2004 https://doi.org/10.1080/02841850410008405
  4. Hori A : Suprasellar peri-infundibular ectopic adenohypophysis in fetal and adult brains. J Neurosurg 63 : 113-115, 1985 https://doi.org/10.3171/jns.1985.63.1.0113
  5. Horiuchi T, Tanaka Y, Kobayashi S, Unoki T, Yokoh A : Rapidly-growing ectopic pituitary adenoma within the sphenoid sinus. Case report. Neurol Med Chir (Tokyo) 37: 399-402, 1997 https://doi.org/10.2176/nmc.37.399
  6. Kohno M, Sasaki T, Narita Y, Teramoto A, Takakura K : Suprasellar ectopic pituitary adenoma. Case report. Neurol Med Chir (Tokyo) 34 : 538-542, 1994 https://doi.org/10.2176/nmc.34.538
  7. Lee SY, Heo SH, Chung JG, Jang YG, Gill SB : Ectopic piuitary adenoma within the sphenoid sinus. Case report. J Korean Neurosurg Soc 30 : 227-230, 2001
  8. Luk KH, Lam KS, Kung AW, Fung CF, Leung SY : Suprasellar ectopic pituitary adenoma presenting as cranial diabetes insipidus. Postgrad Med J 68: 467-469, 1992 https://doi.org/10.1136/pgmj.68.800.467
  9. Mitsuya K, Nakasu Y, Nioka H, Nakasu S : Ectopic growth hormonereleasing adenoma in the cavernous sinus. case report. Neurol Med Chir(Tokyo) 44: 380-385, 2004 https://doi.org/10.2176/nmc.44.380
  10. Peker S, Sun I, Kurtkaya-Yapicier O, Elmaci I, Pamir MN : Ectopic pituitary adenoma located at the pituitary stalk. case report. J Neurosurg Sci 49 : 25-29, 2005