Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Microbleeds in Patients with Primary Intracerebral Hemorrhages

  • Kim, Il-Man (Departments of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Yim, Man-Bin (Departments of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Son, Eun-Ik (Departments of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Sohn, Sung-Il (Departments of Neurology, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Sohn, Chul-Ho (Departments of Diagnostic Radiology, Dongsan Medical Center, Keimyung University School of Medicine)
  • Published : 2006.03.30
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Abstract

Objective : We investigate risk factors of cerebral microbleeds[MBs] and their relation to concomitant magnetic resonance[MR] findings in intracerebral hemorrhages[ICHs] patients. Methods : We studied 100 consecutive patients with primary ICH over a 1-year period. These patients underwent brain MR images using 3.0-T scanners within the first week of the hemorrhage. MBs and old hematomas were located and counted by using $T2^*-weighted$ gradient-echo MR imaging. We also counted lacunes and graded white matter and periventricular hyperintensity on T1- and T2-weighted spin-echo sequences. The association between MBs and vascular risk factors and MR abnormalities were analyzed. Results : MBs were seen in 77 of ICH patients, and their number ranged from 1 to 65 lesions [mean 11, median 6]. The locations of MBs were subcortex-cortex [40.6%], basal ganglia [26.7%], thalamus [14.1 %], brain stem [12.5%], and cerebellum [9.1 %]. Analysis of clinical data revealed that age, hypertension, history of stroke, and duration of hypertension were frequently associated with MBs. The incidence of lacunes, old hematomas, and advanced leukoaraiosis was significantly higher in the MBs group, compared with the patients without MBs. Conclusion : MBs are frequently observed in ICH patients with advancing age, chronic hypertension, and previous hemorrhagic stroke, and are also closely related with morphological signs of occlusive type microangiopathy, such as lacunar infarct and severe leukoaraiosis.

Keywords

References

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