Central Neurocytoma

  • Shin, Seung-Ho (Department of Neurosurgery, Research Institute of Clinical Medicine, Chonbuk National University Medical School/Hospital) ;
  • Koh, Eun-Jeong (Department of Neurosurgery, Research Institute of Clinical Medicine, Chonbuk National University Medical School/Hospital) ;
  • Choi, Ha-Young (Department of Neurosurgery, Research Institute of Clinical Medicine, Chonbuk National University Medical School/Hospital)
  • Published : 2006.02.28

Abstract

Central neurocytoma is a rare, well-differentiated neuronal tumor and is usually located in the lateral or third ventricle of young adults. The occurrence of an intraventricular tumor with a characterisitic magnetic resonance image findings including isointense signal in T1-weighted images, the presence of a cystic component, small signal-void areas due to calcification, heterogenous and hyperintense "bubbly" appearance in T2-weighted images in a young patient should suggest preoperatively the diagnosis of central neurocytoma. The typical immunohistochemical finding, positivity for synaptophysin, is the main pathological feature. We experienced two cases of central neurocytomas with typical radiological and histopathological findings. We expect growth arrest of these cases by subtotal removal to avoid postoperative neurologic deficit followed by radiation therapy.

Keywords

References

  1. Choi YS, Song YJ, Huh KY, Kim KU : Malignant variant of the central neurocytoma. J Korean Neurosurg Soc 35 : 313-316, 2004
  2. Jamshid J, Shuichi I, Toshiki Y, Motohiko M : Central neurocytoma presenting with intratumoral hemorrhage. Neurosurg Rev 24 : 48-52, 2001 https://doi.org/10.1007/PL00011968
  3. Kim DG, Kim JS, Chi JG, Park SH, Jung HW, Choi KS, et al : Central neurocytoma; proliferative potential and biological behavior. J Neurosurg 84 : 742-747, 1996 https://doi.org/10.3171/jns.1996.84.5.0742
  4. Kim DG, Paek SH, Kim IH, Chi JG, Jung HW, Han DH, et al : Central neurocytoma; The role of radiation therapy and long term outcome. Cancer 79 : 1995-2002, 1997 https://doi.org/10.1002/(SICI)1097-0142(19970515)79:10<1995::AID-CNCR22>3.0.CO;2-P
  5. Maiuri F, Spaziante R, De Caro ML, Cappabianca P, Giamundo A, Iaconetta G : Central neurocytoma : clinico-pathological study of 5 cases and review of the literature. Clin Neurol Neurosurg 97 : 219-228, 1995 https://doi.org/10.1016/0303-8467(95)00031-E
  6. Osborn AG : Diagnostic imaging Brain, ed 1. Salt Lake City : Amirsys, 2004, ppI680-I683
  7. Spiros S, Carey M, Aluwlhare N, Barber P, Jackowski A : Central neurocytoma : a correlative clinicopathologic and radiologic analysis. Surg Neurol 49 : 197-204, 1998 https://doi.org/10.1016/S0090-3019(97)00017-7
  8. Yasargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD : Central neurocytoma : histopathological variants and therapeutic approaches. J Neurosurg 76 : 32-37, 1992 https://doi.org/10.3171/jns.1992.76.1.0032