Microcystic Meningiomas: Its Immunohistochemical and Genetic Aspect

  • Koo, Sang-Keun (Department of Neurosurgery, Brain Tumor Institute, College of Medicine, Dong-A University) ;
  • Han, Jin-Yeong (Department of Laboratory Medicine, Brain Tumor Institute, College of Medicine, Dong-A University) ;
  • Kim, Su-Jin (Department of Pathology, Brain Tumor Institute, College of Medicine, Dong-A University) ;
  • Kim, Ki-Uk (Department of Neurosurgery, Brain Tumor Institute, College of Medicine, Dong-A University)
  • Published : 2006.02.28

Abstract

The authors report three microcystic meningiomas with its characteristic immunohistochemical findings and chromosomal pattern. Three patients with surgically treated microcystic meningioma were studied for its radiological, histopathological findings, and chromosomal analysis was done in the one patient. Tumors were convexity meningioma in the frontal area. The tumors were enhanced homogenously in the two, and enhanced in homogenously with multiple small cysts in the other one on preoperative magenetic resonance image. Pathological examination showed marked nuclear pleomorphism, many small cysts, hyaline thickening in blood vessel wall, and mucinous background, compatable to microcystic type. EMA and vimentin were positive on the immunohistochemical stain. Chromosomal analysis showed tetrasomies of chromosome 5, 13, 17, and 20, and trisomies of chromosome 6, 7, 9, 11, 12, 16, 19, and 21, which are quite different from those of benign meningioma.

Keywords

References

  1. Carvalho GA, Vorkapic P, Biewener G, Samii M : Cystic meningiomas resembling glial tumors. Surg Neurol 47 : 284-289, 1997 https://doi.org/10.1016/S0090-3019(96)00361-8
  2. De Jesus O, Rifkinson N, Negron B : Cystic meningiomas : a review. Neurosurgery 36 : 489-492, 1995 https://doi.org/10.1227/00006123-199503000-00007
  3. El-Fiki M, El-Henawy Y, Abdel-Rahman N : Cystic meningioma. Acta Neurochir 138 : 811-817, 1996 https://doi.org/10.1007/BF01411258
  4. Fukuoka K, Hirokawa M, Kanahara T, Ishii N, Ishii R, Shirabe T : Cytology of microcystic meningioma in crush preparation. Diagn Cytopathol 23 : 275-278, 2000 https://doi.org/10.1002/1097-0339(200010)23:4<275::AID-DC12>3.0.CO;2-I
  5. Kim HS, Jang SJ, Jeong SH : Microcystic Meningioma : A Case Report. J Korean Neurosurg Soc 27 : 1271-1276, 1998
  6. Kleihues P, Burger PC, Scheithauer BW : The new WHO classification of brain tumors. Brain Pathol 3 : 255-268, 1993 https://doi.org/10.1111/j.1750-3639.1993.tb00752.x
  7. Lopez-Gines C, Cerda-Nicolas M, Gil-Benso R, Callaghan R, Collado M, Roldan P, et al : Association of loss of 1p and alterations of chromosome 14 in meningioma progression. Cancer Genet Cytogenet 148 : 123-128, 2004 https://doi.org/10.1016/S0165-4608(03)00279-6
  8. Louis DN, Scheithauer BW, Budka H : Meningiomas. In Kleihues P, Cavenee WK(eds) : Pathology and Genetics of Tumors of the Nervous System, IARC Press, pp176-180
  9. Maillo A, Diaz P, Sayagues JM, Blanco A, Tabernero MD, Ciudad J, et al : Gains of chromosome 22 by fluorescence in situ hybridization in the context of an hyperdiploid karyotype are associated with aggressive clinical features in meningioma patients. Cancer 92 : 377-385, 2001 https://doi.org/10.1002/1097-0142(20010715)92:2<377::AID-CNCR1333>3.0.CO;2-W
  10. Michaud J, Gagne F : Microcystic meningioma. Clinicopathologic report of eight cases. Arch Pathol Lab Med 107 : 75-80, 1983
  11. Mihaila D, Jankowski M, Gutierrez JA, Rosenblum ML, Newsham IF, Bogler O, et al : Meningiomas : loss of heterozygosity on chromosome 10 and marker-specific correlations with grade, recurrence, and survival. Clin Cancer Res 9 : 4443-4451, 2003
  12. Ng HK, Tse CC, Lo ST : Microcystic meningiomas--an unusual morphological variant of meningiomas. Histopathology 14 : 1-9, 1989 https://doi.org/10.1111/j.1365-2559.1989.tb02109.x
  13. Odake G : Cystic meningioma : report of three patients. Neurosurgery 30 : 935-940, 1992
  14. Paik SS, Jang SJ, Park YW, Hong EK, Park MH, Lee JD : Microcystic meningioma. A case report. J Korean Med Sci 11 : 540-543, 1996 https://doi.org/10.3346/jkms.1996.11.6.540
  15. Pinna G, Beltramello A, Buffatti P, Signorini G, Colombari R, Bricolo A, et al : Cystic meningiomas-an update. Surg Neurol 26 : 441-452, 1986 https://doi.org/10.1016/0090-3019(86)90256-9
  16. Quest DO : Meningiomas : an update. Neurosurgery 3 : 219-225, 1978 https://doi.org/10.1227/00006123-197809000-00016
  17. Paek SH, Kim SH, Chang KH, Park CK, Kim JE, Kim DG, et al. Microcystic meningiomas : radiological characteristics of 16 cases. Acta Neurochir(Wien) 147 : 965-972, 2005 https://doi.org/10.1007/s00701-005-0578-3