Journal of Korean Physical Therapy Science (대한물리치료과학회지)

Korean Physical Therapy Science (대한물리치료과학회)
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Endothelin-l as a Regulator of Vascular Smooth Muscle Contraction-related Signal Transduction and Endothelin-l-induced Pain-related Nociception -The Approach of Basic Physical Therapy for the Study of Pain Specialized Physical Therapy-

혈관평활근 수축-연관 신호전달 체계에 대한 Endothelin-1의 역할과 Endothelin-1-유도통증-연관 유해감각 -통증전문물리치료 연구를 위한 기초물리치료학적 접근을 중심으로-

  • Kim, Jung-Hwan (Dept. of Physical Therapy, Yongin University) ;
  • Lee, Sook-Hee (Dept. of Senior Rehabilitation Welfare, Yongin University) ;
  • Lee, Sang-Bin (Dept. of Physical Therapy, Pohang 1 College) ;
  • Choi, Yoo-Rim (Min's Research Center) ;
  • Kim, Bo-Kyung (Min's Research Center) ;
  • Park, Ju-Hyun (Dept of Physical Therapy, the Graduate School of Rehabilitation and Health Science, Yongin University) ;
  • Koo, Ja-Pung (Dept of Physical Therapy, the Graduate School of Rehabilitation and Health Science, Yongin University) ;
  • Choi, Wan-Suk (Dept. of Physical Therapy, Pohang 1 College) ;
  • An, Ho-Jung (Dept of Physical Therapy, Pyoungchon Sungshim Hospital) ;
  • Choi, Jeong-Hyun (Dept of Physical Therapy, Pyoungchon Sungshim Hospital) ;
  • Kim, Moo-Gi (Dept of Pain Specialized Physical Therapy, Hanmaun Hospital) ;
  • Kim, Soon-Hee (Dept. of Physical Therapy, Yongin University)
  • 김중환 (용인대학교 물리치료학과) ;
  • 이숙희 (용인대학교 노인재활복지학과) ;
  • 이상빈 (포항1대학 물리치료과) ;
  • 최유림 (민-물리치료연구센터) ;
  • 김보경 (민-물리치료연구센터) ;
  • 박주현 (용인대학교 재활보건과학대학원 물리치료학과) ;
  • 구자풍 (용인대학교 재활보건과학대학원 물리치료학과) ;
  • 최완석 (포항1대학 물리치료과) ;
  • 안호정 (평촌성심병원 물리치료실) ;
  • 최정현 (평촌성심병원 물리치료실) ;
  • 김무기 (한마음병원 통증전문물리치료실) ;
  • 김순희 (용인대학교 물리치료학과)
  • Published : 2006.06.30
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Abstract

Endothelin (ET) is a 21 amino acid peptide with multifunctional effects on the vasculature as well as a variety of other cell types such as respiratory, gastrointestinal, urogenital, endocrine, central nervous systems, and others. Endothelin has emerged as a modulator by autocrine and paracrine actions for many cellular activities, including vasoconstriction, cell proliferation, hormone production, neurotransmitter and/or neuromodulator. The endothelin family consists of three closely related peptides, ET-1, ET-2, and ET-3 derived from separate genes, such as chromosome 6, 1, and 20, respectively. ET-1 is the predominant isoform produced in the cardiovascular system and about which most is known. Endothelin receptors are seven-transmembrane GTP-binding protein-coupled receptors, which are classified into endothelin-A (ETA) and endothelin-B (ETB) receptors. Interestingly, recent evidence is accumulating to suggest that ET -1 may contribute to a variety of pain states such as allodynia and hyperalgesia in animals and humans. Therefore, in this review the biological characteristics and contraction-related mechanism of endothelin-1 in mammalian cells will be summarized. Especially, we focus on multifunctional roles for ET-1 in noxious stimulation-induced pain for the study of pain specialized physical therapy.

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