A facile synthesis of 4-cyano-3,5-difluorophenol

4-cyano-3,5-difluorophenol의 새로운 합성법

4-Cyano-3,5-difluorophenol, useful as intermediate in the manufacturing of liquid crystals, was prepared by the regioselective iodination of 3,5-difluorophenol to give 4-iodo-3,5-difluorophenol, which was then converted to 4-cyano-3,5-difluorophenol under a mild reaction condition. The reaction products were characterized by spectroscopic methods and confirmed by comparison of these analytical data with reported values in the literatures.

액정재료의 중간체로 사용되는 4-cyano-3,5-difluorophenol를 3,5-difluorophenol을 출발물질로 하여 요오드 치환반응 및 시안화학반응으로 이루어지는 2 단계로 합성하였다. 생성된 4-cyano-3,5-difluorophenol은 분광학적 방법으로 분석하여 표준 시료와 비교 확인되었다.