한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제23권4권
  • /
  • Pages.421-426
  • /
  • 2006
  • /
  • 1598-298X(pISSN)
  • /
  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

돼지 적출 자궁 평활근의 운동성에 있어서 transmural nerve stimulation에 대한 ${\beta}$-adrenergic 신경의 이완작용

Relaxative Effect of Transmural Nerve Stimulation via ${\beta}$-adrenergic Nerve on the Isolated Uterine Smooth Muscle Motility of Pigs

  • 김주헌 (경상대학교 수의과대학, 동물의학연구소) ;
  • 전제철 (경상대학교 수의과대학, 동물의학연구소) ;
  • 노규진 (경상대학교 수의과대학, 동물의학연구소) ;
  • 홍용근 (인제대학교 의생명공학대학, 심혈관 및 대사성질환 센터) ;
  • 최상용 (경상대학교 수의과대학, 동물의학연구소)
  • Kim, Joo-Heon (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Jeon, Jae-Cheul (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Rho, Gyu-Jin (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Hong, Yong-Geun (Cardiovascular & Metabolic Disease Center College of Biomedical Science and Engineering, Inje University) ;
  • Choe, Sang-Yong (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 발행 : 2006.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The effects of transmural nerve stimulation induced releasing neurotransmitters on the changes of swine uterine smooth muscle motility were examined by polygraph through isometric force transducer. The frequency dependent relaxation and rebound contraction were revealed on precontraction with histamine by transmural nerve stimulation. The rebound contraction by transmural nerve stimulation was inhibited by nonselective ${\alpha}$-adrenergic receptor antagonist, phentolamine, and the relaxation by transmural nerve stimulation was blocked by nonselective ${\beta}$-adrenergic receptor antagonist, propranolol. The relaxation induced by nonselective ${\beta}$-adrenergic receptor agonist, isoproterenol on precontraction with histamine were the dose dependent manner and this relaxation was blocked by nonselective ${\beta}$-adrenergic receptor antagonist, propranolol in isolated uterine smooth muscle of pig. These results suggest that endogenous neurotransmitters on smooth muscle relaxation was influenced by ${\beta}$-adrenergic receptor in swine.

키워드

참고문헌

  1. Ahquist RP. A study of the adrenotropic receptor. Am J Physiol 1948; 153: 586-600
  2. Alexandrova M, Soloff MS. Oxytocin receptors and parturition. I. control of oxytocin receptor concentration in the rat myometrium at term. Endocrinol 1980; 106: 730-735 https://doi.org/10.1210/endo-106-3-730
  3. Bolton TB. Mechanism of action of transmitters and other substances on smooth muscle. Physiol Rev 1979; 220: 606-718
  4. Brause MM, Bumstock G. Expression of $\beta$-adrenergic receptors in the rat uterus: Effects of puberty and estrogen treatment during prepubertal development. Int J Devel Neurosci 1998; 16: 29-39 https://doi.org/10.1016/S0736-5748(97)00047-6
  5. Bulletti C, de Ziegler D, de Moustier B, Polli V, Bolelli G, Franceschetti F, Flamigni C. Uterine contractility: Vaginal administration of the $\beta$-adrenergic agonist, terbutaline. Evidence of direct vagina-to-uterus transport. Ann NY Acad Sci 2001; 943: 163-171 https://doi.org/10.1111/j.1749-6632.2001.tb03800.x
  6. Buyukafsar K, Levent A, Un I, Ark M, Arikan O, Ozveren E. Mediation of nitric oxide from photosensitive stores in the photorelaxation of the rabbit corpus cavemosum. Eur J Pharmacol 2003; 459: 263-267 https://doi.org/10.1016/S0014-2999(02)02858-3
  7. Cao J, Yosida M, Kitazawa T, Taneike T. Uterine region-dependent differences in responsiveness to prostaglandins in the non-pregnant myometrium. Prostaglandins Other Lipid Mediat 2005; 75(1-4): 105-122 https://doi.org/10.1016/j.prostaglandins.2004.08.002
  8. Coleman AJ, Paterson DS, Smoerville AR. The $\beta$-adrenergic receptor of rat corpus luteum membrane. Biochem Pharmacol 1979; 28: 1003-1012 https://doi.org/10.1016/0006-2952(79)90294-6
  9. Cook RD, Burnstock G. The ultrastructure of auerbach's plexus in guinea pig. I. Neural element. J Neurocytol 1976; 5: 171-194 https://doi.org/10.1007/BF01181655
  10. EI-Mahmoudy A, Khalifa M, Draid M, Shiina T, Shimizu Y, EI-Sayed M, Takewaki T. NANC inhibitory neuromuscular transmission in the hamster distal colon. Pharmacol Res 2006; in press
  11. Gonella J. Modification of electrical activity of the longi-tudinal muscle of the rabbit duodenum following contraction of the circular muscle. Rens Romani Gastroenterol 1971; 3: 127-131
  12. Fushs AR, Periyasamy S, Alexandrova M, Soloff MS. Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium: Effect of ovarian steroid. Endocrinol 1983; 113: 742-749 https://doi.org/10.1210/endo-113-2-742
  13. Johns A, Coons LW. Physiological and pharmacological characteristics of the Baboon (Papio-anubis) oviduct. Biol Reprod; 1981: 25: 120-127 https://doi.org/10.1095/biolreprod25.1.120
  14. Kim JH, Shim CS, Hong YG. Effect of transmural stimulation to motility on isolated gastric smooth muscle. Korean J Vet Res 1999; 39: 472-477
  15. Labate JS. Influence of cocaine on the uterine reaction induced by adrenaline and hypogastric nerve stimulation. J Pharmarcol Exp Ther 1941; 72(3): 370-382
  16. Lands AM, Arnold A, McAuliff JP, Laduena FP, Brown TG lr. Differentiation of receptor systems activated by sympathomimetic amines. Nature 1967; 21: 597-598 https://doi.org/10.1038/021597a0
  17. Langendijk P, Bouwman EG, Kidson A, Kirkwood RN, Soede NM, Kemp B. Role of myometrium activity in sperm transport through the genital tract in fertilization in sows. Reproduction 2002; 123: 683-690 https://doi.org/10.1530/rep.0.1230683
  18. Liu YL, Nwosu DC Rice PJ. Relaxation of isolated human myometrial muscle by $\beta$2-adrenergic receptors but not $\beta$1-adrenergic receptors. Am J Obstet Gynecol 1998; 179: 895-898 https://doi.org/10.1016/S0002-9378(98)70185-1
  19. Marshall JM. Effects of catecholamines on the smooth muscle of the female reproductive tract. Am Rev Pharmscol 1973; 13: 19-24
  20. Mhaouty-Kodja S, Houdeau E, Legrand C. Regulation of myometrial phospholipase C system and uterine contraction by $\beta$-adrenergic receptors in midpregnant rat. Biol Reprod 2004; 70: 570-576 https://doi.org/10.1095/biolreprod.103.021535
  21. Rodriguez-Martinez H, Einarsson S, Larsson. Spontaneous motility of the oviduct in the anaesthetized pig. J Reprod Fert 1982; 66: 615-524 https://doi.org/10.1530/jrf.0.0660615
  22. Segal S, Csavoy AN, Datta S. The tocolytic effect of catecholamines in the gravid rat uterus. Anesth Analg 1998; 87: 864-869 https://doi.org/10.1097/00000539-199810000-00022
  23. Seibold A, Williams B, Huang ZF, Friedman J, Moore RH, Knoll BJ, Clark RB. Localization of the sites mediating desensitization of the $\beta_2$-adrenergic receptors by the GRK pathway. Mol Pharmacol 2000; 58: 1162-1173 https://doi.org/10.1124/mol.58.5.1162
  24. Simon V, Mhaouty-Kodja S, Legrand C, Cohen-Tannougji J. Concomitant increase of G-protein-coupled receptor kinase activity and uncoupling of $\beta$-adrenergic receptor in rat myometrium at parturition. Endocrinol 2001; 142: 1899-1905 https://doi.org/10.1210/en.142.5.1899
  25. Simon V, Robin MT, Legrand C, Cohen-Tannoudji J. Endogenous G- protein-coupled receptor kinase 6 triggers homogous $\beta$-adrenergic receptor desensitization in primary uterine smooth muscle cells. Endocrinol 2003; 144: 3058-3066 https://doi.org/10.1210/en.2002-0138
  26. Taneike T, Narita T, Kitazawa T, Bando S, Teraoka H, Ohga A. Binding and functional characterization of alpha-2 adrenoceptors in isolated swine myometrium. J Auton Pharmacol 1995; 15(2): 93-105 https://doi.org/10.1111/j.1474-8673.1995.tb00295.x
  27. Thilander G, Eriksson H, Edqvist LE, Rodriguez-Martinez H. Progesterone and oestradiol-17 beta receptor in the porcine myometrium during the oestrous cycle. Zentralbl Veterinary med A. 1990; 37(5): 321-328 https://doi.org/10.1111/j.1439-0442.1990.tb00912.x
  28. Thilander G, Eriksson H, Edqvist LE, Rodriguez-Martinez H. Variations in oestradiol and progesterone receptor levels in the porcine myometrium and cervix during pregnancy and parturition. Zentralbl Veterinarmed A. 1990; 37(5): 329-338 https://doi.org/10.1111/j.1439-0442.1990.tb00913.x
  29. William LT, Lefkowitz RJ. $\alpha$-adrenergic receptor identification by 3H dihydrocryptine binding. Science 1976; 3: 127-131
  30. Zupko I, Marki A, Gaspar R, Falkay G. Correlation between $\alpha$/$\beta$-adrenoceptor ratio and spontaneous uterine motor activity in the post-partum rat. Mol Human Reprod 1998; 4: 921-924 https://doi.org/10.1093/molehr/4.9.921