정보처리학회논문지B (The KIPS Transactions:PartB)

한국정보처리학회 (Korea Information Processing Society)
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특징 추출과 분석 기법에 기반한 단백질 상호작용 데이터 신뢰도 향상 시스템

Protein-Protein Interaction Reliability Enhancement System based on Feature Selection and Classification Technique

  • 이민수 (이화여자대학교 컴퓨터학과) ;
  • 박승수 (이화여자대학교 컴퓨터학과) ;
  • 이상호 (이화여자대학교 컴퓨터학과) ;
  • 용환승 (이화여자대학교 컴퓨터학과) ;
  • 강성희 (명지대학교 방목기초교육대학)
  • 발행 : 2006.12.31
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초록

대용량 실험으로부터 산출된 단백질 상호작용 데이터는 위양성(false positive) 데이터의 비율이 높다는 단점을 가지고 있다. 본 논문에서는 오류가 섞여있는 단백질 상호작용 데이터를 입력으로 받아 각 단백질 상호작용의 신뢰도를 검증하는 시스템을 제안하고 구현하였다. 제안 시스템은 단백질 상호작용 데이터에 상호작용의 근거로서 사용될 수 있는 다양한 생물학적 특징들에 관한 데이터를 통합하고 특징 선택 방법을 사용하여 통합된 속성들 중 위양성 여부를 판별하는데 가장 적합한 특징들을 선택한 후 데이터 마이닝 분류 알고리즘을 적용하여 대용량 실험으로부터 산출된 단백질 상호작용 데이터의 신뢰도를 평가한다. 특징 선택의 결과와 분류 기법의 성능은 데이터 특성에 매우 의존하므로, 제안시스템에 가장 적합한 속성 부분집합과 가장 좋은 성능을 내는 분류 알고리즘을 찾기 위해 다양한 특징 선택 방법과 데이터 마이닝 분류 알고리즘들을 적용하고 그 성능을 다각적으로 비교분석 하였다. 실험 결과, 특징 선택 방법과 분류 알고리즘을 결합시킨 제안 시스템은 오류 데이터가 섞여있는 단백질 상호작용 데이터에서 실제로 상호작용하는 단백질 쌍을 골라내는 작업에 있어 기존 연구들에 비해 매우 뛰어난 성능을 보여줬다. 또한 본 연구를 통해 단백질 상호작용 데이터의 신뢰도를 검증함에 있어서 다양한 특징 선택 방법들과 분류 알고리즘들이 성능에 미치는 영향에 관해서도 정리할 수 있었다.

Protein-protein interaction data obtained from high-throughput experiments includes high false positives. In this paper, we introduce a new protein-protein interaction reliability verification system. The proposed system integrates various biological features related with protein-protein interactions, and then selects the most relevant and informative features among them using a feature selection method. To assess the reliability of each protein-protein interaction data, the system construct a classifier that can distinguish true interacting protein pairs from noisy protein-protein interaction data based on the selected biological evidences using a classification technique. Since the performance of feature selection methods and classification techniques depends heavily upon characteristics of data, we performed rigorous comparative analysis of various feature selection methods and classification techniques to obtain optimal performance of our system. Experimental results show that the combination of feature selection method and classification algorithms provide very powerful tools in distinguishing true interacting protein pairs from noisy protein-protein interaction dataset. Also, we investigated the effects on performances of feature selection methods and classification techniques in the proposed protein interaction verification system.

키워드

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