생명과학회지 (Journal of Life Science)

  • 제16권7호
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  • Pages.1127-1132
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  • 2006
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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콜레스테롤 식이를 섭취한 흰쥐에 새송이버섯이 지질대사 및 효소활성에 미치는 영향

Effects of Pleurotus eryngii on Lipid Levels and Enzyme Activity in Male Rats Fed High Cholesterol Diets

  • 이충언 (신라대학교 생물과학과)
  • 발행 : 2006.12.01
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초록

새송이버섯이 고콜레스테롤 식이를 섭취한 흰쥐의 지질대사에 미치는 영향을 조사하고자, 생후 8주령 숫쥐를 정상식이군, 대조식이군(5% 옥수수기름, 5% 돈지 및 0.5% 콜레스테롤을 첨가한 식이) 및 대조식이에 새송이버섯 분말을 3% 및 5%씩 첨가한 식이군 (3% 및 5% 새송이버섯군) 등 4군으로 나누어 4주간 사육한 결과는 다음과 같다. 실험동물의 체중증가량 및 식이효율은 대조군에 비하여 3% 및 5% 새송이버섯군이 유의하게 감소되었다. 간과 부고환지방의 무게는 대조군에 비해 5% 새송이버섯군이 유의하게 감소되었다. 간의 콜레스테롤 및 중성지질 농도는 대조군에 비하여 5% 새송이버섯군이 유의하게 감소되었다. 혈청의 중성지 질, 총 콜레스테롤과 LDL+VLDL-콜레스테롤 농도 및 동맥경화지수는 대조군에 비해 새송이버섯군들이 유의하게 감소되었다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비율은 대조군에 비해 새송이버섯군들이 유의하게 증가되었다. 변의 지질배설량은 5% 새송이버섯군이 대조군 보다 유의하게 증가된 것으로 나타났다 이상의 결과로 보아 고콜레스테롤 식이에 새송이버섯 분말 첨가 급여시 흰쥐의 일부 지질대사를 개선시키는 것으로 나타났다.

Effects of dietary supplementation of Pleurotus eryngii(PE) to a diet containig the cholesterol on lipid levels in the liver and serum, and enzyme activities of rats were studied by feeding 8-weeks old male rats with the four diets for 4 weeks, respectively: normal diet, control diet (10% fat + 0.5% cholesterol), 3% and 5% PE diets (control diet + 3% and 5% PE dry powder). The body weight gains and food efficiency ratios of the 3% and 5% PE diet groups were significantly lower than those of the control group. The liver and epididymal fat pad weights, and hepatic triglyceride Levels of the 5% PE diet group were more significantly decreased than those of the control group. The concentrations in serum triglyceride, total cholesterol, LDL+VLDL-cholesterol, and atherogenic index ratios were significantly lower in the 3% or 5% PE groups compared to those of the control group. Ratio of HDL-cholesterol to total-cholesterol was significantly higher in the 3% and 5% PE groups compared to that of the control group. The fecal total lipid excretion of the 5% PE diet group was more significantly decreased than that of the control group. There was no significant difference in the hepatic cholesterol, and the serum HDL-cholesterol concentrations, and the GOT, GPT and ${\gamma}-GTP$ activities among the experimental groups. These results showed that the Pleurotus eryngii powder feeding decreased the total cholesterol, LDL-cholesterol and atherogenic index, and increased the ratio of HDL-cholesterol to total-cholesterol in serum of the rats.

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