Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of the Feral Peach (Prunus persica Batsch var. davidiana Max) Extract on the Lipid Compositions and Blood Pressure Level in Spontaneously Hypertensive Rats

야생 돌복숭아(Prunus persica Batsch var. davidiana Max.) 추출액이 선천성 고혈압 흰쥐의 지질성분 및 혈압 저하에 미치는 영향

  • Kim, Han-Soo (School of Applied Life Science, Pusan National University)
  • 김한수 (부산대학교 생명응용과학부)
  • Published : 2006.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to observe the effects of the feeding physiological activity substance in feral peach(Prunus Persica Batsch var. davidiana Max.) extract intake on the improvement of the lipid compositions, apolipoprotein and blood pressure level in spontaneously hypertensive rats(SHR, Wistar strain, male) fed the experimental diets for 33 days. Concentrations of total cholesterol, triglyceride(TG), LDL-cholesterol, free cholesterol and atherosclerotic index in serum were significantly lower in the feral peach extract intake groups[groups 5g% Ex.(basal diet+feral peach 5.0g% extract), 10g% Ex.(basal diet+feral peach 10.0g% extract)] than those in the group Control(basal diet+water). In the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration, feral peach 5.0g%, 10.0g% extract intake groups(group 5g% Ex. and 10g% Ex.) were higher percentage than in the group Control. However, concentrations of total cholesterol and TC in liver and brain were significantly lower in the groups 5g% Ex. and 10g% Ex. than those in the group Control. But the concentrations of apolipoprotein (Apo) A-I and Apo A-II in serum were significantly higher in the feral peach 5.0g% and 10.0g% extract intake groups(5g% Ex. and 10g% Ex.) than in the control group. However, concentrations of Apo C-II, Apo C-III, Apo E and ratio of Apo B to Apo A-I in serum were fairly reduced in the groups 5g% Ex. and 10g% Ex. than in the control group. The levels of systolic and diastolic blood pressure were significantly lower in feral peach 5g% Ex. and 10g% Ex. groups than control group. However, no significance was found in the effect of among the groups(groups 5g% Ex. and 10g% Ex.). From these results, physiological activity substance in feral peach(Prunus persica Batsch var. davidiana Max.) extracts were effective on the improvement of the lipid compositions and cardiovascular heart disease, hypertension in spontaneously hypertensive rats. And particularly, feral peach extracts were more effective as a therapeutic regimen for the control of blood pressure in hypertension.

야생 돌복숭아(Prunus persica Batsch var. davidiana Max.)의 생리활성 추출물질이 선천성 고혈압 흰쥐(SHR)의 지질대사 이상 및 고혈압 예방과 개선효과 등에 생리생화학적 효능이 있을 것으로 추정되어 Wistar 계 수컷 SHR을 사용하여, 기본식이와 물만을 급여한 대조군인 Control군과 SHR에 돌복숭아 5.0g% 추출액을 급여한 군(5g% Ex.군) 및 SHR에 돌복숭아 10.0g% 추출액을 섭취시킨 10g% Ex.군을 33일간 실험 사육하여 혈청 지질성분 및 혈압 저하 효과를 생리적 측면에서 검토하기 위하여 본 실험을 수행하였다. 혈청 중의 총 콜레스테롤 농도, 중성지방, LDL-콜레스테롤, 유리 콜레스테롤 및 동맥경화지수 등에서 돌복숭아 생리활성물질 5.0g%, 10.0g% 추출액을 섭취시킴으로서 유의적인 농도 등의 감소 효과를 보였으며, HDL-콜레스테롤 농도 및 총 콜레스테롤에 대한 HDL-콜레스테롤 비는 상승되는 것으로 나타났다. 한편, 간장 및 뇌 중의 총 콜레스테롤, 중성지방 농도는 돌복숭아 5.0g%, 10.0g% 추출액을 섭취시킨 군에서 감소되는 것으로 나타났다. 반면, 혈청 apolipoprotein(Apo) A-I, Apo A-II 농도 등은 돌복숭아 5.0g%, 10.0g% 추출액을 섭취시킨 군에서 유의적으로 증가되는 것으로 나타났다. 또한 Apo C-II, Apo C-III, Apo E 및 Apo A-I에 대한 Apo B의 농도 비는 감소되었으며, 혈압의 변화는 SHR에 돌복숭아 5.0g% 및 10.0g% 추출액을 섭취시킴으로서 혈압이 저하됨을 관찰할 수가 있었다. 돌복숭아 5.0g% 농도(5g% Ex.군)와 10.0g% 농도(10g% Ex.군)의 추출액 섭취에 따른 두 군간에 각종 지질성분과 apolipoprotein 분획 농도 및 혈압 변화의 비교는 유의적인 차이는 없었다 따라서 야생 돌복숭아 중의 생리활성물질 추출액 섭취가 선천성 고혈압 흰쥐에 대한 혈청 지질개선 및 심장순환기계 질환, 고혈압의 예방과 치료개선에 효과가 있을 것으로 생각된다.

Keywords

References

  1. Ahn, K. H. 1980. Atlas to canons of primitive-modern oriental medicine. pp. 205-206, Seowondang, Seoul, Korea
  2. An, B. J., J. T. Lee, J. M. Park, J. H. Kwak, J. Y. Lee, C. I. Park, J. H. Son and H. Y. Lim. 2003. Chemical structure and isolation of novel anti-hypertensive ingredient as condensed tannin from the pods of Korean Caesalpinia sepiaria. Korean J. Herbology 18, 235-243
  3. Applebaum, B. D., S. M. Haffner, E. Hartsook, K. H. Luk, J. J. Albers and W. R. Hazzard. 1984. Down regulation of the low density lipoprotein receptor by dietary cholesterol. Am. J. Clin. Nutr. 39, 360-367 https://doi.org/10.1093/ajcn/39.3.360
  4. Bae, J. S., B. Y. Kang, K. T. Kim, J. H. Shin and C. C. Lee. 2001. Study on the mutation screening of the apolipoprotein C-II gene in Korean hypertensives and the association with plasma triglyceride level. Korean J. Lipidol. Atheros. 11, 515-525
  5. Breckenridag, W. C., J. A. Little, G. Steiner, A. Chow and M. Poapst. 1978. Hypertriglyceridemia associated with deficiency of apolipoprotein C-II. New Engl. J. Med. 298, 1265-1273 https://doi.org/10.1056/NEJM197806082982301
  6. Breslow, J. L. 1993. Genetics of lipoprotein disorder. Circulation 87, 16-21
  7. Brewer, H. B. 2004. High density lipoproteins: a new potential therapeutic target for the prevention of cardiovascular disease. Arterioscler. Thromb. Vase. Biol. 24, 387-391 https://doi.org/10.1161/01.ATV.0000121505.88326.d2
  8. Cha, B. C. and E. H. Lee. 2004. Antioxidant and antiinflammation activities of Prunus persica tree extracts. Korean J. Medicinal Crop Sci. 12, 289-294
  9. Cho, H. K. 2006. Diabetes mellitus and disorder of lipid metabolism. Korean J. Endocrin. 21, 101-105 https://doi.org/10.3803/jkes.2006.21.2.101
  10. Choi, B. H., S. L. Kim and S. K. Kim. 1996. Rutin and functional ingredients of buckwheat and their variations. Korean J. Crop Sci. 41, 69-93
  11. Choi, H. J., Y. H. Whang, U. H. Pek and H. S. Shin. 1990. Effect of dietary grape seed oil in serum lipids in spontaneously hypertensive rats. Korean J. Nutr. 23, 467-476
  12. Choi, M, S., D. H. Do and D. J. Choi. 2002. The effect of mixing beverage with Aralia continentalis kitagawa root on blood pressure and blood constituents of the diabetic and hypertensive elderly. Korean J. Food Nutr. 15, 165-172
  13. Chung, J. H., C. K. Mok, S. B. Lim and Y. S. Park. 2003. Changes of physicochemical properties during fermentation of peach wine and quality improvement by ultrafiltration. J. Korean Soc. Food Sci. Nutr. 32, 506-512 https://doi.org/10.3746/jkfn.2003.32.4.506
  14. Chung, S. Y. and H. S. Kim. 1994. Hyperlipidemia, atherosclerosis and nutrition. pp. 34-47, Habdong Publishing Company, Korea
  15. Do, S. G., P. W. Choi, J. G. Suh, C. S. Kim, H. K. Shin, M. H. Won, M. H. Lee and Y. S. Oh. 1999. Effects of garlic on the blood pressure of spontaneously hypertensive rats(SHR). Korean J. Lab. Anim. Sci. 15, 275-282
  16. Flesch, M., A. Sachinidis, Y. D. Ko, K. Kraft and H. Vetter. 1994. Plasma lipids and lipoproteins and essential hypertension. Clin. Invest. 72, 944-950 https://doi.org/10.1007/BF00577733
  17. Goldstein, J. L. and M. S. Brown. 1983. The LDL receptor defect in familial hypercholesterolemia: Implications for pathogenesis and therapy. Med. Clin. North Am. 66, 335-362
  18. Hamet, P., L. Richard, T. V. Dam, E. Teiger, S. N. Orlov, L. Gabouryl, F. Gossard and J. Tremblay. 1995. Apoptosis in target organs of hypertension. Hypertension 26, 642-648 https://doi.org/10.1161/01.HYP.26.4.642
  19. Joossens, J. V. and J. Geboers. 1987. Dietary salt and risk to health. Am. J. Clin. Nutr. 45, 1277-1288 https://doi.org/10.1093/ajcn/45.5.1277
  20. Kannel, W. B., T. R. Dawber and P. Sorlie, 1976. Components of blood pressure and risk of athrothrombotic brain infarction. Stroke 7, 327-331 https://doi.org/10.1161/01.STR.7.4.327
  21. Katayama, K., H. Fuchu, M. Sugiyama, S. Kawahara, K. Yamauch, Y. Kawamura and M. Muguruma. 2003. Peptic hydrolysates of porcine crude myosin has many active fractions inhibiting angiotensin-I converting enzyme. Asian-Aus. J. Anim. Sci. 16, 1384-1389 https://doi.org/10.5713/ajas.2003.1384
  22. Kim, D. H., K. S. Lee and B. K. Song. 2000. A study on the analgesic and anticoagulative effects of Persicae semen and Carthami flos of aqua-acupuncture. J. Oriental Gynecology 13, 60-73
  23. Kim, H. S. 2002. Effects of the Zizyphus jujuba seed extract on the lipid components in hyperlipidemic rats. J. Food Sci. Nutr. 7, 72-77 https://doi.org/10.3746/jfn.2002.7.1.072
  24. Kim, H. S. 2004. Effects of the Prunus persica Batsch var. davidiana Max. extract on the lipid compositions and enzyme activities in hyperlipidemic rats. Korean J. Food Nutr. 17, 328-336
  25. Kim, H. S. 2004. Effects of the Prunus persica Batsch var. davidiana Max. extract on the blood glucose and serum lipid components in streptozotocin-induced diabetic rats. Korean J. Food Nutr. 17, 337-345
  26. Kim, H. S. 2005. Effects of Prunus persica Batsch var. davidiana Max. extract on the free fatty acid, creatine phosphokinase and LCAT activities in hypercholesterolemic rats. Korean J. Food Nutr. 18, 265-271
  27. Kim, H. S. 2005. The effects of Prunus persica Batsch var. davidiana Max. hot-water extract on the lipid peroxide and creatine phosphokinase activity in streptozotocin-induced diabetic rats. Korean J. Food Nutr. 18, 272-278
  28. Kim, J. K., T. W. Park, C. J. Lee and Y. G. Chai. 1999. Protective effect of peach kernel extracts on radiation-induced DNA damage in human blood lymphocytes in the comet assay. Korean Nuclear Soc. Bull. 99, 388
  29. Kim, K. H. 1980. The clinical application of the results of the test. pp. 164-176, Komoonsa, Seoul, Korea
  30. Kim, K, J., J. R Do and H. K. Kim. 2005. Antimicrobial, antihypertensive and anticancer activities of garlic extracts. Korean J. Food Sci. Technol. 37, 228-232
  31. Kim, S. S. 1985. Resent theory of hypertension in adults. J. Korean. Med. Asso. 28, 396-399
  32. Kunio, S. 1998. Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L. (garlic). J. Nutr. Biochem. 9, 415-419 https://doi.org/10.1016/S0955-2863(98)00036-9
  33. La Rosa, J. C., R. I. Levy, P. N. Herbert, S. E. Lux and D. S. Fredrickson. 1970. A specific apoprotein activator for lipoprotein lipase. Biochem. Biophys. Res. Commun. 41, 57-72 https://doi.org/10.1016/0006-291X(70)90468-7
  34. Lee, J. S., S. J. Park, K. S. Sung, C. K. Han, M. H. Lee, C. W. Jung and T. B. Kwon. 2000. Effects of germinated-buckwheat on blood pressure, plasma glucose and lipid levels of spontaneously hypertensive rats. Korean J. Food Sci. Technol. 32, 206-211
  35. Lee, J. Y., S. G. Hong and S. W. Choi. 2000. Inhibition of enzymatic browning of apple juices by benzoic acid isolated from peach(Prunus persica Batsch) seeds. Korean J. Postharvest Sci. Technol. 7, 103-107
  36. McConathy, W. J., J. C. Gesquiere, H. Bass, A. Tartar, J. C. Fruchart and C. S. Wang. 1992. Inhibition of lipoprotein lipase activity by synthetic pep tides of apolipoprotein C-III. J. Lipid Res. 33, 995-1003
  37. Nestel, P. J., N. Havenstein, H. M. Whyte, T. J. Scott and L. J. Cook. 1973. Lowering of plasma cholesterol and enhanced sterol excretion with the consumption of polyunsaturated ruminant fats. New Engl. J. Med. 288, 379-382 https://doi.org/10.1056/NEJM197302222880801
  38. Packard, C., M. Caslake and J. Shepherd. 2000. The role of small dense low density lipoprotein(LDL): a new look. Int. J. Cardiol. 74, S17-S22 https://doi.org/10.1016/S0167-5273(99)00107-2
  39. Park, E. R., J. O. Jo and K. S. Kim. 1991. Volatile flavor components in various varieties of peach(Prunus persica L.) cultivated in Korea. Korean J. Postharvest Sci. Technol. 6, 206-215
  40. Park, J. H., S. H. Han, M. K. Shin, K. H. Park and K. C. Lim. 2002. Effect of hypertension falling of functional GABA green tea. Kerean Med. Crop Sci. 10, 37-40
  41. Potter, S. M., R. M. Bakhit, D. L. Essexsorlie, K. E. Weingartner, K. M. Chapman, R. A. Nelson, M. Prabhudesai, W. D. Savage, A. I. Nelson and I. W. Winter. 1993. Depression of plasma cholesterol in men by consumption of baked products containing soy protein. Am. J. Clin. Nutr. 58, 501-506 https://doi.org/10.1093/ajcn/58.4.501
  42. Ryu, W. S., U. H. Ryoo, Y. S. Choi, H. S. Lee and S. H. Cho. 1993. Periodic changes in levels of lipid peroxide and vitamin E in spontaneously hypertensive rats fed high cholesterol diet. Korean J. Lipidology 3, 123-132
  43. Segreat, J., L. Li, G. M. Ananthatamaiah, S. C. Harvey, K. N. Liadaki and V. Zannis. 2000. Structure and function of apolipoprotein A-I and high density lipoprotein. Curr. Opin. Lipidol. 11, 105-115 https://doi.org/10.1097/00041433-200004000-00002
  44. Shin, K. K. 1973. Shin's Herbology. pp. 562-564, Soomoonsa, Seoul, Korea
  45. Smith, E. B. 1974. The relationship between plasma and tissue lipid in human atherosclerosis. Adv. Lipid Res. 11, 1-7
  46. Sniderman, A. D., A. C. St-Pierre, B. Cantin, G. R. Dagenais, J. P. Despres and B. Lamarche. 2003. Concordance/ discordance between plasma apolipoprotein B levels and the cholesterol indexes of atherosclerotic risk. Am. J. Cardiol. 91, 1173-1177 https://doi.org/10.1016/S0002-9149(03)00262-5
  47. Swales, J. D. 1984. Aetiology of hypertension. Br. J. Anaesth. 56, 677-688 https://doi.org/10.1093/bja/56.7.677
  48. The Korean Pharmacognosy Professor Association. 1994. Herbology. pp. 526-528, The Korean Pharmaceutical Association, Seoul, Korea
  49. Tiret, L., P. de Knijff, H. Menzel, C. Ehnholm, V. Nicaud and L. M. Havekes. 1994. Apo E polymorphism and predisposition to coronary heart disease in youths different European populations. Arterioscler. Thromb. 14, 1617-1624 https://doi.org/10.1161/01.ATV.14.10.1617
  50. Windler, E. and R. S Havel. 1985. Inhibitory effects of apolipoproteins C from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26, 556-565
  51. Yi, K. N. and C. S. Rhee. 1996. Clinical pathology file. pp.101-126, Euihakmunwhasa, Seoul, Korea
  52. Yoon, I. H, B. I. Seo and S. H. Kim. 1996. The effect of Persicae semen on the atherosclerosis in rabbit. J. Herbology 11, 79-98

Cited by

  1. Triterpenoids from the fruits ofPrunus davidiana vol.59, pp.2, 2016, https://doi.org/10.3839/jabc.2016.028
  2. Effect of Clerodendron trichotomum Thunberg tea on anti-hypertension vol.30, pp.4, 2015, https://doi.org/10.6116/kjh.2015.30.4.129.
  3. Effect of Cynanchi wilfordii Radix Extracts on Lipid Compositions and Blood Pressure in Spontaneously Hypertensive Rats vol.41, pp.3, 2012, https://doi.org/10.3746/jkfn.2012.41.3.345