Nutritional Sciences

The Korean Nutrition Society (한국영양학회)
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Clinical Study on the Iron Absorption from Heme-Iron Polypeptide and Nonheme-Iron

  • Nam, Tae-Sik (Department of Biochemistry, Chonbuk National University) ;
  • Shim, Ji-Yeon (Department of Biochemistry, Chonbuk National University) ;
  • Kim, Byung-Ju (Department of Biochemistry, Chonbuk National University) ;
  • Rah, So-Young (Department of Biochemistry, Chonbuk National University) ;
  • Park, Kwang-Hyun (Department of Biochemistry, Chonbuk National University) ;
  • Kim, Seon-Young (Department of Biochemistry, Chonbuk National University) ;
  • Mun, Eun-Gyeng (Department of Food Science & Human Nutrition, Chonbuk National University) ;
  • Jeong, Young-Ju (Department of Obstetrics, Chonbuk National University) ;
  • Han, Myung-Kwan (Department of Microbiology, Chonbuk National University) ;
  • Cha, Youn-Soo (Department of Food Science & Human Nutrition, Chonbuk National University) ;
  • Chae, Soo-Wan (Institute of Cardiovascular Research, Chonbuk National University) ;
  • Im, Mie-Jae (Department of Biochemistry, Chonbuk National University) ;
  • Kim, Uh-Hyun (Institute of Cardiovascular Research, Chonbuk National University)
  • Published : 2006.11.30
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Abstract

Iron bound to heme appears to be more bioavailable than iron salts. A clinical study was performed to investigate the absorption efficiency of heme-iron and iron-salt products available. Heme-iron and nonheme-iron supplements have become available in Korea. We performed iron absorption studies to compare the absorption of heme-iron polypeptide (HIP) products made from digested hemoglobin, produced in Korea (HIPk) and imported from Japan (HIj), with that of iron salts. In the study, 80 subjects were divided into 5 groups (n=56): placebo group; 12 mg glucose, HIPk group; 12 mg iron as HIPk, HIj group; 12 mg iron as HIj, iron-salt group 1; 12 mg of iron as ferrous aminoacetate, and iron-salt group 2; 100 mg iron as ferrous aminoacetate. Changes in serum iron levels were measured at 3 and 5 hours post ingestion. Absorption of iron in HIPk was higher compared to HIj, iron-salt or placebo. There was a significant inverse correlation between low serum iron levels $(<80{\mu}g/dl)$ and iron absorption from HIPk. These results demonstrated that HIPk was more bioavailable, even taken with a meal, and would have potential advantages over iron salt or HIj as an iron supplement. Our results indicate that heme-iron absorption is regulated by iron status through a heme receptor, whereas iron-salt absorption is unregulated.

Keywords

References

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