References
- Akao, T., H. Kida, M. Kanaoka, M. Hattori, and K. Kobashi. 1988. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol. 50: 1155-1160
- Bae, E. A., M. J. Han, M. K. Choo, S. Y. Park, and D. H. Kim. 2002. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol. Pharm. Bull. 25: 58-63 https://doi.org/10.1248/bpb.25.58
-
Bae, E. A., S. Y. Park, and D. H. Kim. 2000. Constitutive
${\beta}$ -glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm. Bull. 23: 1481-1485 https://doi.org/10.1248/bpb.23.1481 - Bae, E. A., M. K. Choo, E. K. Park, S. Y. Park, H. Y. Shin, and D. H. Kim. 2003. Metabolism of ginsenoside Rc by human intestinal bacteria and its related antiallergic activity. Biol. Pharm. Bull. 25: 743-747
- Bae E.-A., J.-E. Shin, S.-H. Park, and D.-H. Kim. 2004. Inhibitory effect of ginseng polysaccharides on rotavirus infection. J. Microbiol. Biotechnol. 14: 202-204
- Bielory, L. 2004. Complementary and alternative interventions in asthma, allergy, and immunology. Ann. Allergy Asthma Immunol. 93(2 Suppl 1): S45-S54 https://doi.org/10.1016/S1081-1206(10)61486-X
- Bruhns, P., S. Fremont, and M. Daeron. 2005. Regulation of allergy by Fc receptors. Curr. Opin. Immunol. 17: 662-669 https://doi.org/10.1016/j.coi.2005.09.012
- Choo, M. K., E. K. Park, M. J. Han, and D. H. Kim. 2003. Antiallergic activity of ginseng and its ginsenoside. Planta Med. 69: 518-522 https://doi.org/10.1055/s-2003-40653
- Cox, J. S. G. 1967. Disodium cromglycate (FPL-670) ('Intar'): A specific inhibitor of reaginic antibody-antigen mechanism. Nature 216: 1326-1329
- Hernandez, G. L., O. V. Volpert, M. A. Iniguez, E. Lorenzo, S. Martinez-Martinez, R. Grau, M. Fresno, and J. M. Redondo. 2001. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase 2. J. Exp. Med. 193: 607-620 https://doi.org/10.1084/jem.193.5.607
- Ito H., T. Miyazaki, M. Ono, and H. Sakurai. 1998. Antiallergic activities of rabdosiin and its related compounds: Chemical and biochemical evalutions. Bioorg. Med. Chem. 6: 1051-1056 https://doi.org/10.1016/S0968-0896(98)00063-7
- Keum, Y. S., S. S. Han, K. S. Chun, K. K. Park, J. H. Park, S. K. Lee, and Y. J. Surh. 2003. Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. Mutat. Res. 523-524: 75-85 https://doi.org/10.1016/S0027-5107(02)00323-8
- Kim, D. S., N. I. Baek, J. D. Park, Y. H. Lee, S. Y. Jeong, C. B. Lee, and S. I. Kim. 1995. Preparation and structure determination of a new glycoside, (20E)-ginsenoside Rh3, and its isomer from diol-type ginseng saponins. Yakhak Hoeji 39: 85-93
- Kim, S. I., J. H. Park, J. H. Ryu, J. D. Park, Y. H. Lee, J. H. Park, T. H. Kim, J. M. Kim, and N. I. Baek. 1996. Ginsenoside Rg5, a genuine dammarane glycoside from Korean red ginseng. Arch. Pharm. Res. 19: 551-553 https://doi.org/10.1007/BF02986026
- Kim, J.-M., J.-E. Shin, M. J. Han, S.-H. Park, and D.-H. Kim. 2003. Inhibitory effect of ginseng saponins and polysaccharides on infection and vacuolation of Helicobacter pylori. J. Microbiol. Biotechnol. 13: 706-709
- Kim, W. K., P. G. Jang, M. S. Woo, I. O. Han, H. Z. Paik, K. Lee, H. Lee, T. Joh, and H. S. Kim. 2004. A new anti-inflammatory agent KL-1037 represses pro-inflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia. Neuropharmacology 47: 243-252 https://doi.org/10.1016/j.neuropharm.2004.03.019
- Kitagawa, I., M. Yoshikawa, M. Yoshihara, T. Hayashi, and T. Taniyama. 1983. Chemical studies of crude drugs (1). Constituents of Ginseng radix rubra. Yakugaku Zasshi 103: 612-622 https://doi.org/10.1248/yakushi1947.103.6_612
- Kown, S. W., S. B. Han, I. H. Park, J. M. Kim, M. K. Park, and J. H. Park. 2001. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J. Chromatogr. A 921: 335-339 https://doi.org/10.1016/S0021-9673(01)00869-X
-
Mastuda, H., T. Morikawa, K. Ueda, H. Managi, and M. Yoshikawa. 2002. Structural requirement of flavonoids for inhibition of antigen-induced degranulation, TNF-
${\alpha}$ and IL- 4 production from RNL-2H3 cells. Bioorg. Med. Chem. 10: 2123-3128 - Mochizuki, M., C. Y. Yoo, K. Matsuzawa, K. Sato, I. Saiki, S. Tono-oka, K. Samukawa, and I. Azuma. 1995. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of Red ginseng. Biol. Pharm. Bull. 18: 1197-1202 https://doi.org/10.1248/bpb.18.1197
- Nicoloff, B. J. 1991. The cytokine network in psoriasis. Arch. Dermatol. 127: 871-884 https://doi.org/10.1001/archderm.127.6.871
- Park, B. K., M. Y. Heo, H. Pak, and H. P. Kim. 2001. Inhibition of TPA-induced cyclooxygenase-2 and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur. J. Pharmacol. 425: 153-158 https://doi.org/10.1016/S0014-2999(01)01187-6
- Park, I. H., N. Y. Kim, S. B. Han, J. M. Kim, S. W. Kwon, H. J. Kim, M. K. Park, and J. H. Park. 2002. Three new dammarane glycosides from heat processed ginseng. Arch. Pharm. Res. 25: 428-432 https://doi.org/10.1007/BF02976595
- Park, E. K., M. K. Choo, E. J. Kim, M. J. Han, and D. H. Kim. 2003. Antiallergic activity of ginsenoside Rh2. Biol. Pharm. Bull. 26: 1581-1584 https://doi.org/10.1248/bpb.26.1581
- Park, E. K., M. K. Choo, M. J. Han, and D. H. Kim. 2004. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol. 133: 113-120 https://doi.org/10.1159/000076383
-
Park, S.-Y., J.-H. Kim, and D.-H. Kim. 2005. Purification and characterization of quercitrin-hydrolyzing ct-
$_L$ -rhamnosidase from Fusobacterium K-60, a human intestinal bacterium. J. Microbiol. Biotechnol. 15: 519-524 - Plaut, M., J. H. Pierce, C. Whatson, J. Hanley-Hyde, R. P. Nordan, and W. E. Paul. 1989. Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophore. Nature 339: 64-67 https://doi.org/10.1038/339064a0
- Reynolds, N. J., J. J. Voorhees, and G. H. Fisher. 1998. Cyclosporin A inhibits 12-O-tetradecanoyl-phorbol-13-acetate-induced cutaneous inflammation in severe combined immunodeficient mice that lack fuctional lymphocytes. Br. J. Dermatol. 139: 16-22 https://doi.org/10.1046/j.1365-2133.1998.02307.x
- Sakuma, S., Y. Higashi, N. Sato, T. Sasakawa, T. Sengoku, Y. Ohkubo, T. Amaya, and T. Goto. 2001. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (comparison with steroids). Int. Immunopharmacol. 1: 1219-1226 https://doi.org/10.1016/S1567-5769(01)00059-5
- Schafer-Korting, M., M. H. Schmid, and H. C. Korting. 1996. Topical glucocorticoids with improved risk-benefit ratio. Drug Safety 14: 375-385 https://doi.org/10.2165/00002018-199614060-00003
- Shibata, S., M. Fujita, H. Itokawa, O. Tanaka, and T. Ishii. 1963. Panaxadiol, a sapongenin of ginseng roots (1). Chem. Pharm. Bull. 11: 759-764 https://doi.org/10.1248/cpb.11.759
- Shin, Y. W., E. A. Bae, S. S. Kim, Y. C. Lee, and D. H. Kim. 2005. Int. Immunopharmacol. 5: 1183-1191 https://doi.org/10.1016/j.intimp.2005.02.016
- Simons, F. E. 1992. The antiallergic effects of antihistamines (H1-receptor antagonists). J. Allergy Clin. Immunol. 90: 705-715 https://doi.org/10.1016/0091-6749(92)90156-V
- Stevens, R. L. and K. F. Austen. 1989. Recent advances in the cellular and molecular biology of mast cells. Immunol. Today 10: 381-386 https://doi.org/10.1016/0167-5699(89)90272-7
- Tanaka, N., O. Tanaka, and S. Shibata. 1972. Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng; Stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc. Chem. Pharm. Bull. 20: 1212-1216 https://doi.org/10.1248/cpb.20.1212
- Wakabayashi, C., H. Hasegawa, J. Murata, and I. Saiki. 1998. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 9: 411-417
- Wu, J. Y., B. H. Gardner, C. I. Murphy, J. R. Seals, C. R. Kensil, J. Recchia, G. A. Beltz, G. W. Newman, and M. J. Newman. 1992. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. J. Immunol. 148: 1519-1525
- Wuthrich, B. 1989. Epidemiology of the allergic diseases: Are they really on the increase? Int. Arch. Allergy Appl. Immunol. 90(Suppl. 1): 3-10 https://doi.org/10.1159/000235067
- Yang, S. H., C. Y. Hong, and C. L. Yu. 2001. Decreased serum IgE level, decreased IFN-gamma and IL-5 but increased IL-10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. Int. Immunopharmacol. 1: 1173-1182 https://doi.org/10.1016/S1567-5769(01)00051-0