EFFECT OF DIFFERENT SURFACE TREATMENTS TO INCREASE BIOCOMPATIBILITY OF DENTAL IMPLANT

임플랜트 표면처리가 생체활성에 미치는 영향

  • Lee, Ho-Jin (Department of Prosthodontics, Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Song, Kwang-Yeob (Department of Prosthodontics, Institute of Oral Bioscience, School of Dentistry, Chonbuk National University) ;
  • Yoon, Tae-Ho (Department of Prosthodontics, Institute of Oral Bioscience, School of Dentistry, Chonbuk National University)
  • 이호진 (전북대학교 치과대학 보철학교실, 구강생체과학연구소) ;
  • 송광엽 (전북대학교 치과대학 보철학교실, 구강생체과학연구소) ;
  • 윤태호 (전북대학교 치과대학 보철학교실, 구강생체과학연구소)
  • Published : 2006.10.31

Abstract

Statement of problem: Modification of titanium implant surface has potential to ensure clinically favorable performance that several surface modification technologies have been introduced. Among the methods. anodizing method and sol-gel hydroxyapatite coating method have gained much interest due to its roughness and chemical composition of the coating layer, but more of its biocompatibility result is required. Purpose : The purpose of this study was to compare bone-implant interface shear strength of four different surface treated implants as time elapsed. Resonance frequency analysis(RFA) and removal torque measurement methods were employed to measure implant stability at one week and six week after implantation. Material and method: A total of 80 screw-shaped implant [20 machined, 20 resorbable media blasted(RBM), 20 anodized, and 20 anodized+hydroxyapatite sol-gel coated] were prepared, and one of each group was implanted in the tibia of a New Zealand white rabbit that total 20 of them were used. In order to test the implant stability and implant-tissue interface contact changing in the bone bed, each 10 rabbit were sacrificed 1 week and 6 week later while resonance frequency and removal torque were measured. One-way analysis of variance and the Tukey test were used for statistical analysis. Results : The results were as follows. 1. There was no statistically significant difference of implant stability quotients(ISQ) value in RFA between individual groups after 1 week of implantation and 6 weeks(p>0.05). But, there was statistically significant increase of ISQ value in 6 weeks group compared to 1 week group(p<0.05). 2. There was no statistically significant difference in removal torque analysis between individual groups after 1 week of implantation and 6 weeks(p>0.05). but there was statistically significant increase in all 4 groups after 6 weeks compared to 1 week later(p<0.05). 3. There was no statistically significant difference in removal torque analysis between anodized group and HA coating after anodic oxidation 6 weeks later(p>0.05), but significant difference was appeared in both groups compared to RBM group and smooth-machined group(p<0.05). Conclusions : It can be suggested that changes in surface characteristics affect bone reactions. Anodized and anodized+hydroxyapatite sol-gel coating showed significantly improved bone tissue response to implants, but further study on the effect of hydroxyapatite dissolution is needed.

Keywords

References

  1. Long M. Rack HJ. Titanium alloys in total joint replacement: A materials science perspective. Biomaterials 1998;19:1621-1639 https://doi.org/10.1016/S0142-9612(97)00146-4
  2. Gu H. Xu G. Biomedical material science. Tianjin: Science Translation Press; 1993
  3. Wilke A. Landgraff M, Orth J, Kienpfel H, Grissand P, Franke R. Human bone marrow cell cultures: A sensitive method for determination of the biocompatibility of implant materials. ATLA 1999;27:137-151
  4. Brunette DM, Tengvall P, Textor M, Thomsen P. Titanium in medicine. Berlin:Springer;2001
  5. Quirynen M. Bollen CM, Papaioannou W, Van Eldere J, van Steenberghe D. The influence of titanium abutment surface roughness on plaque accumulation and gingivitis: Short-tern observations. Int J Oral Maxillofac Implants 1996;11:169-178
  6. Hutton JE, Health MR, Chai JY, Harnett J, Jemt T. Johns RB. Factors related to success and failure rates at 4-year followup in a multicenter study of overdentures supported by Branemark implants. Int J Oral Maxillofac Implants 1995;10:334
  7. Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mat Res 1991;25:889-902 https://doi.org/10.1002/jbm.820250708
  8. Gottlaner M, Albrektsson T. Histomorphometric studies of hydroxylapatitecoated and uncoated CP titanium threaded implants in bone. Int J Oral and Maxillofac Implants 1991;6:399-404
  9. Wennerberg A, Albrektsson T, Andersson B. Design and surface characteristics of 13 commercially available oral implant systems. Int J Oral and Maxillofac Impl 1993;8:622633
  10. Rompen E, DaSilva D, Lundgren AK. Stability measurements of a doublethreaded titanium implant design with turned or oxidized surface. Applied Osseointegration Research 2001;2:1820
  11. Glauser R, Portmann M, Ruhstaller P. Initial implant stability using different implant designs and surgical techniques. Applied Osseointegration Research 2001; 2:6-8
  12. Cooper LF. A role for surface topography in creating and maintaining bone at titanium endosseous implants. J Prosthet Dent 2000;84:522-534 https://doi.org/10.1067/mpr.2000.111966
  13. Wennerberg A, Albrektsson T, Andersson B, Eng M, Design and surface characteristics of 13 commercially available oral implant systems, Int J Oral Maxillofac Implants 1993;11:38-45
  14. Kim YH, Heo SJ. A histomorphometric analysis for the effect of various surface treatment methods on the osseointegration. J Korean Acad Prosthodont 2004;42:318-329
  15. Piattelli M, Scarano A, Paolantonio M, Iezzi G, Petrone G, Piattelli A. Bone response to machined and resorbable blast material titanium implants: An experimental study in rabbits. J Oral Implantol 2002;28:2-8 https://doi.org/10.1563/1548-1336(2002)028<0002:BRTMAR>2.3.CO;2
  16. Sanz A, Oyarzun A, Farias D, Diaz I. Experimental study of bone response to a new surface treatment of endosseous titanium implants. Implant Dent 2001; 10:126-131 https://doi.org/10.1097/00008505-200104000-00009
  17. Deporter DA, Watson PA, Pilliar RM. A histological assessment of the initial healing response adjacent to porous surfaced Ti alloy dental implants in dogs. J Dent Res 1986;65:1064-1070 https://doi.org/10.1177/00220345860650080501
  18. Pilliar RM, Deporter PA, Watson PA. The effect of partial coating with hydroxyapaite on bone remodeling in relation to porous-coated titanium-alloy dental implants in the dog. J Dent Res 1991;70:1338-1345 https://doi.org/10.1177/00220345910700100501
  19. Branemark PI. Introduction to osseointegration. Tissue-integrated prostheses. Osseointegration in clinical dentistry. Chicago, Quintessence Publishing Co 1986:11-76
  20. Adell R, Eriksson B, Lekholm U, Branemark PI, Jemt T. A long-term follow-up study of osseointegrated implants in the treatment of totally edentulous jaws. Int J Oral and Maxillofac Implants 1990;5:347-359
  21. Van Steenberge D, Lekholm U, Bolender C, Folmer T, Henry P, Herrmann I. The applicability of osseointegrated oral implants in the rehabilitation of partial edentulism. A prospective multicenter study of 558 fixtures. Int J Oral and Maxillofac Implants 1990;5:271-281
  22. Meredith N. On the clinical measurement of implant stability and osseointegration. Thesis. Department of Biomaterials/Handicap Research, Institude for Surgical Sciences, Gothenburg University. Gothenberg, Sweden. 1997
  23. Meredith N, Alleyne D, Cawley P. Quantitative determination of the stability of the implant-tissue interface using resonance frequency analysis. Clin Oral Impl Res 1996:7:261 https://doi.org/10.1034/j.1600-0501.1996.070308.x
  24. Meredith N, Book K, Friberg B, Jemt T, Sennerby L. Resonance frequency measurements of implant stability in vivo. Clin Oral Implant Research 1997:8:226 https://doi.org/10.1034/j.1600-0501.1997.080309.x
  25. Meredith N, Rasmussen L, Sennerby L, Alleyne D. Mapping implant stability by resonance frequency analysis. Med Sci Research 1996:24:191
  26. Johansson C, Albrektsson T. Integration of screw implant in the rabbit. A one year follow up of removal torque of titanium implants. Int J Oral Maxillofac Implants 1987:2:69-75
  27. Ivanoff CJ, Sennerby L, Lekholm U. Influence of mono and bicortical anchorage on the integration of titanium implants. A study in the rabbit tibia. Int J Oral Maxillofac Surg 1996:25:229-235 https://doi.org/10.1016/S0901-5027(96)80036-1
  28. Kwak MB, Lee CH. The evaluation of the removal torque and the histomorphometry of the Ca-P coating surface in rabbit tibia. J Korean Acad Prosthodont 2004:42:556-571
  29. Albrektsson T, Jacobsson M. Bone-metal interface in osseointegration. J Prosthet Dent 1987:57:597-607 https://doi.org/10.1016/0022-3913(87)90344-1
  30. Carlsson L, Rostlund T, Albrektsson B, Albrektsson T. Implant fixation improved by close fit. Cylindrical implant-bone interface studied in rabbits. Acta Orthop Scand 1988:59:272-275 https://doi.org/10.3109/17453678809149361
  31. Larsson C, Thomsoen P, Aronsson BO. Bone response to surface modified titanium implants. Studies on the tissue response after one year to machined and electropolished implants with different thickness. J Mat Sci Materials in medicine 1997:8:721-729 https://doi.org/10.1023/A:1018548225899
  32. Sul YT. On the bone response to oxidized titanium implants: The role of microporous structure and chemical composition of the sulfide oxide in enhanced osseointegration(thesis). Goteborg, Sweden: Goteborg Univ, 2002
  33. Cheang P, Khor KA. Addressing processing problems associated with plasma spraying of hydroxyapatite coatings. Biomaterials 1996:17:537-544 https://doi.org/10.1016/0142-9612(96)82729-3
  34. Wheeler SL. Eight-year clinical retrospective study of titanium plasma-sprayed and hydroxyapatite coated cylinder implants. Int J Oral Maxilofac Implants 1996:11 :340-350
  35. Ishizawa H, Fujino M, Ogino M. Mechanical and histological investigation of hydrothermally treated and untreated anodic titanium oxide films containing Ca and P. J Biomedical Materials Research, 1995:29:1459-1468 https://doi.org/10.1002/jbm.820291118
  36. Li LH, Kim HW, Lee SH, Kong YM, Kim HE. Biocompatibility of titanium implants modified by micro arc oxidation and hydroxyapatite coating. J Biomed Mater Res 2005:73A:48-54 https://doi.org/10.1002/jbm.a.30244
  37. Kim SJ, Shin SW, Jung SM, Ryu JJ. A study on the stability of 5 different surface treatment methods to dental implant using resonance frequency and histomorphometric analysis. J Korean Acad Prosthodont 2005:43:78-92
  38. Shulte W. The Periotest periodontal status. Zahnarztl Mitt 1986:76:1
  39. Shulte W. A new field of application of the Periotest method. The occlusal-periodontal load can now be measured quantitatively. Zahnarztl Mitt 1988:78:474
  40. Derhami K, Wolfaardt JF, Dent M, Faulkner G, Grace M. Assessment if the periotest device in base line mobility measurements of craniofacial implants. Int J Oral Maxillofac Implants 1995:10:221
  41. Meredith N, Shagaldi F, Alleyne D, Sennerby L, Cawley P. The application of resonance frequency measurements to study the stability of titanium implants during healing in the rabbit tibia. Clin Oral Implants Res 1997:8:234-243
  42. Choi JW, Heo SJ, Chang IT, Koak JY, Han JH, Kim YS, Lee SH, Yim SH. Resonance frequency analysis of implants with anodized surface oxides. J Kor Acad Prosthodont 2004:42:305-311