대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제27권5호
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  • Pages.224-228
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  • 2006
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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Polyurethane과 Poly(Ethylene Oxide)를 이용한 hybrid 나노섬유 지지체의 제작

Dual Electrospinning to Manufacture Hybrid Nanofibrous Scaffold using Polyurethane and Poly(Ethylene Oxide)

  • 신지원 (인제대학교 의용공학과 BK21 사업단) ;
  • 신호준 (일본 자이스트 재료과학과) ;
  • 허수진 (인제대학교 의용공학과 BK21 사업단) ;
  • 김지희 (인제대학교 의용공학과 BK21 사업단) ;
  • 황영미 (인제대학교 의용공학과 BK21 사업단) ;
  • 김동화 (인제대학교 의용공학과 BK21 사업단) ;
  • 신정욱 (인제대학교 의용공학과 BK21 사업단)
  • Shin, Ji-Won (Team of BK21 / Dept. of Biomedical engineering, Inje University) ;
  • Shin, Ho-Jun (School of Material Science, Japan Advanced Institute of Science and Technology) ;
  • Heo, Su-Jin (Team of BK21 / Dept. of Biomedical engineering, Inje University) ;
  • Kim, Ji-Hee (Team of BK21 / Dept. of Biomedical engineering, Inje University) ;
  • Hwang, Young-Mi (Team of BK21 / Dept. of Biomedical engineering, Inje University) ;
  • Kim, Dong-Hwa (Team of BK21 / Dept. of Biomedical engineering, Inje University) ;
  • Shin, Jung-Woog (Team of BK21 / Dept. of Biomedical engineering, Inje University)
  • 발행 : 2006.10.31
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초록

The object of this study is to investigate the potential of dual-electrospun polymer based structure for vascular tissue engineering, especially for the medium or small sue blood vessels. Polyurethane(PU), which is known to be biocompatible in this area, was electrospun with poly(ethylene oxide) (PEO). Concentration of PU was fixed at 20wt%, while that of PEO was set from 15 to 35wt%. Morphological features were observed by SEM image and measurement of porosity and cellular responses were tested before and after extracting PEO from the hybrid scaffolds by immersing the scaffolds into distilled water. The diameter of PEO fibers were ranged from 200nm to 500nm. The lower concentration of PEO tended to show beads. The porosity of the scaffolds after extracting PEO was highly increased with higher concentration of PEO as expected. Also, higher proliferation rate of smooth muscle cells was observed at higher concentration of PEO than at the lower concentration and without PEO. As conclusions, this dual electrospinning technique combined with PU and PEO is expected to overcome the current barrier of cell penetration by providing more space for cells to proliferation.

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참고문헌

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