Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Effects of the water of yellow soil, Ji-Jang-Soo on cell viability and cytokines production in immune cells

  • Jeong, Hyun-Ja (College of Pharmacy, VCRC of Wonkwang University,College of Oriental Medicine, Kyung Hee University) ;
  • Hwang, Gab-Soo (School of Civil and Environmental Engineering, Kunsan National University) ;
  • Myung, No-Il (College of Pharmacy, VCRC of Wonkwang University) ;
  • Lee, Joon-Ho (College of Pharmacy, VCRC of Wonkwang University) ;
  • Lee, Ju-Young (College of Pharmacy, VCRC of Wonkwang University) ;
  • Um, Jae-Young (College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (College of Pharmacy, VCRC of Wonkwang University)
  • Published : 2006.03.30
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Abstract

Ji-Jang-Soo (JJS) is known to have a detoxification effect. However, it is still unclear how JJS has these effects in experimental models. In this study, we investigated the effect of JJS on the viability of cells and production of cytokines in human T-cell line, MOLT-4 cells, and human mast cell line, HMC-1 cells. The MOLT-4 cells were cultured for 24 h in the presence or absence of JJS. As the result, JJS (1/100 dilution) significantly increased the cell viability about 78% (P < 0.05) and also increased the interleukin (IL)-2, and interferon $(IFN)-{\gamma}$ production compared with media control at 24 h. But had no effect on IL-4 production. Hypoxia mimic compound, desferroxamine (DFX) decreased the immune cell viability. Cell viability decreased by DFX was increased by JJS. In conclusion, these data indicate that JJS may have an immune-enhancing effect.

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References

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