Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Neuropharmacological study of hot water extract of the seeds of Vernonia anthelmintica Kuntze

  • Published : 2006.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

The hot water extract of the seeds of Vernonia anthelmintica Kuntze (Compositae) in a dose of 10 ml/kg body weight of mice, showed significant analgesic activity on the hot plate analgesic method throughout the 4 h experimental period. The hole cross scores and the climbing out scores are of lower than the control animals. The hot water extract reduced the defecation in hole board study and significantly reduces the exploratory ambulation and head dipping behaviour. The seed also showed significant depressant activity on the exploratory ambulation of the open field scores. The drug decreased the spontaneous locomotion activity on brick-chip displacement method up to 45 min and also showed the ability to lessen the amphetamine induced hyperactivity up to 20 min. But it didn't show any effect on pentobarbital induced sleeping time test. The extract reduced gastrointestinal motility.

Keywords

References

  1. Akihisa T, Hayashi Y, Patterson GW, Shimizu N, Tamura T. (1992) $4{\alpha}-Methylvernosterol$ and other sterols from Vernonia anthelmintica seeds. Phytochemistry 31, 1759-1763. https://doi.org/10.1016/0031-9422(92)83142-L
  2. Chatterjee TK. (1993) Handbook of Laboratory Mice and Rats. 1st Edition, p. 157, Department of Pharmaceutical Technology, Jadavpur University, India.
  3. Chopra RN, Ghosh NN, Mukerji AK. (1934) Anthelmintic properties of Vernonia anthelmintica, Willd. (Serrulata anthelmintica). Indian J. Med. Res. 22, 183-186.
  4. Deng R, Zhou Y, Xu J, Shang J, Wang X, Yu L, Zhang J. (2002) Effect of Vernonia anthelmintica willd on the immune function of mice. Zhongguo Mianyixue Zazhi 18, 577-580.
  5. Gupta BD, Dandiya PC, Gupta ML. (1971) A Psycho-pharmacological Analysis of Behavior in Rat. Jpn. J. Pharmacol. 21, 293-298. https://doi.org/10.1254/jjp.21.293
  6. Hannan JMA, Shahriar M, Islam MN, Sattar M, Haque S, Choudhuri MSK. (2003) Neuropharmacological study of some Ayurvedic medicinal plants. Orient. Pharm. Exp. Med. 3, 8-17. https://doi.org/10.3742/OPEM.2003.3.1.008
  7. Lambertini E, Piva R, Khan MTH, Lampronti I, Bianchi N, Borgatti M, Gambari R. (2004) Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene. Int. J. Oncol. 24, 419-423.
  8. Nakama M, Ochiai T, Kowa Y. (1972) Effects of psychotropic drugs on emotional behavior; exploratory behavior of naive rats in holed open field. Jpn. J. Pharmacol. 22, 767-775. https://doi.org/10.1254/jjp.22.767
  9. Saluja KIK, Saxene VK. (1979) Antibacterial activity of essential oils from Vernonia anthelmintica and Viola cinerea. Indian Drugs Pharmaceut. Ind. 14, 29-30.
  10. Sandberg F. (1957) A Comparative Quantitative Study of the Central Depressant Effects of Seven Clinically Used Phenothiazine Derivatives. Arzneimittelforschung 9, 203-206.
  11. Siegmund PN, Wolf M. (1952) Displacement of sand method for the determination of locomotor activity. Arch. Exp. Pathol. Pharmakol. 216, 232-235.
  12. Smith CR, Koch KF, Wolff TA. (1959) Isolation of vernolic acid from Vernonia anthelmintica oil. J. Am. Oil Chemists Soc. 36, 219-220. https://doi.org/10.1007/BF02637913
  13. Takagi K, Watanabe M, Saito H. (1971) Studies on the spontaneous movement of animals by the hole cross test: effect of 2-dimethylaminoethan. Its acylesters on the central nervous system. Jpn. J. Pharmacol. 21, 797-810 https://doi.org/10.1254/jjp.21.797
  14. Tian G, Zhang U, Zhang T, Yang F, Ito Y. (2004) Separation of flavonoids from the seeds of Vernonia anthelmintica Willd by high speed counter current chromatography. J. Chromatogr. A 1049, 219-222. https://doi.org/10.1016/S0021-9673(04)01276-2
  15. Tedeschi DW, Tedeschi RE. (1968) Importance of Fundamental Principles of Drug Evaluation, pp. 307-324, Raven Press, New York.
  16. Wood PL. (1985) Animal Models In Analgesic Testing, p. 183, Raven Press, New York.
  17. Wu J, Musadillin S, Fen S, Kong F, Xu R. (1991) Chemical constituent of Vernonia anthelmintica Willd. Huaxue Xuebao 49, 1018-1022.