Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Three Compounds from Schizandrae Fructus and Uridine on Airway Mucin Secretion

  • Heo, Ho-Jin (Department of Pharmacology, College of Medicin, Chungnam National University) ;
  • Lee, Hyun-Jae (Department of Pharmacology, College of Medicin, Chungnam National University) ;
  • Kim, Cheol-Su (Department of Pharmacology, College of Medicin, Chungnam National University) ;
  • Bae, Ki-Hwan (Department of Pharmacy, College of Pharmacy, Chungnam National University) ;
  • Kim, Young-Sik (Department of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kang, Sam-Sik (Department of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Seo, Un-Kyo (Department of Oriental Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Yun-Hee (Department of Oriental Medicine, College of Oriental Medicine, Daejeon University) ;
  • Park, Yang-Chun (Department of Oriental Medicine, College of Oriental Medicine, Daejeon University) ;
  • Seok, Jeong-Ho (Department of Pharmacology, College of Medicin, Chungnam National University) ;
  • Lee, Choong-Jae (Department of Pharmacology, College of Medicin, Chungnam National University)
  • Published : 2006.09.25
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Abstract

In this study, we investigated whether schizandrin, schizandrin-A, gomisin-A and uridine affect mucin secretion from cultured airway epithelial cells and compared the potential activities of these agents with the inhibitory action on mucin secretion by poly-1-lysine (PLL) and the stimulatory action by adenosine triphosphate (ATP). Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using $^3H-glucosamine$ for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on $^3H-mucin$ secretion. The results were as follows: schizandrin-A and uridine increased mucin secretion at the highest concentrations ($2{\times}10^{-4}\;-\;10^{-3}M$). We conclude that schizandrin-A and uridine can stimulate mucin secretion via direct effect on airway mucin-secreting cells and suggest that these agents be further investigated for the potential use as mucoregulators during the treatment of chronic airway diseases.

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References

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