Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 12 Issue 1
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- Pages.77-89
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- 2006
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- 1229-3377(pISSN)
The Inhibitory Effect of Mahwangbokhapbang 2 on the Obesity
마황복합방(麻黃複合方) 2호(號)가 고지방사료(高脂肪飼料) 식이(食餌)로 유발(誘發)된 비만(肥滿) 생쥐의 혈액 및 조직학적 변화에 미치는 영향(影響)
- Lee, Woo-Youl (College of Oriental Medicine, Daejeon University) ;
- Lim, Byung-Muk (Korea Institute of Oriental Medicine) ;
- Oh, Min-Suck (College of Oriental Medicine, Daejeon University)
- Published : 2006.06.30
Abstract
Objective : This experimental study was designed to investigate the effects of Mahwangbokhapbang2 (every abbreviation from now on MHBHB2) on obesity care where it is prescribed for high fat diet-induced mice. Also designed to find out effects of MHBHB2 on controlling th obesity clinically) Method : In order to investigate th obese inhibitory effects of MHBHB2, C57BL/6 mice were induced by high fat diet C57BL/6 mice were divided into four group(normal, high fat diet, high fat diet with reductil, high fat diet with MHBHB2 extract) and fed for 15weeks. Result : 1. Mahwangbokhapbang2(MHBHB2) decreased significantly the body weig-ht. 2. MHBHB2 decreased significantly the weight of adipocyte. 3. MHBHB2 decreased significantly the blood level of serum ALT, AST. 4. MHBHB2 decreased significantly the blood level of serum total cholester-l, LDL- cholesterol, friglyceride and NEFA(free fatty acid). 5. MHBHB2 decreased significantly the blood level of HDL-cholesterol. 6. MHBHB2 500mg/kg decreased significantly the blood level of Leptin. Conclusion : Based on these results, it is prove that MHBHB2 is effective on obesity care and has obese-inhibitory effects in obese-mouse induced by high fat diet. So it is espected that the clinical application of MHBHB2 can help the treatment of obesity.