Natural Product Sciences

  • 제12권2호
  • /
  • Pages.74-78
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  • 2006
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Studies on the Anti-Inflammatory and Analgesic Effects of Extracts from Marine Sponges

  • 발행 : 2006.06.01
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초록

Two specimens of sponges collected from Red Sea, Egypt, were investigated for their contents of secondary metabolites. The crude extracts of the sponges were tested for their anti-inflammatory and analgesic effects. The toxic effects of the extracts of the two marine sponges were studied. $LD_{50}$ determination revealed that the investigated extracts of 'Igernella and Ircinia spp' were 4.69 and 134.7 mg/l00 g b.wt., respectively, when injected intraperitoneally in mice. The toxic signs were recorded within the first 24 hrs after injection. Also the two marine sponges extracts showed significant anti-inflammatory and analgesic effects.

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참고문헌

  1. Angel, J., Colard, O., Chevy, F, and Fournier C., Inter leukin-I-mediated phospholipid breakdown and arachidonic acid release in human synovial cells. Arthritis Rheum. 36, 158-167 (1993) https://doi.org/10.1002/art.1780360205
  2. Anglo, F., Issa, E, Emesto, M., and Guido C., (-)- Wistarin from the marine sponge Ircinia SP.: the first case of enantiomeric sesterterpenes. Tetrahedron Assymetry. 10,3869-3872 (1999) https://doi.org/10.1016/S0957-4166(99)00406-1
  3. Bongiomi, P.R., and Pietra, E, Marine Natural Products for Industrial Application. Chem.& Ind 2,54-58 (1996)
  4. Charlier, R., Prost, M., Binon, E, and Deltour, G, Pharmacology of an anti-tussive, -1- phenethyl (-2-propynyl) -4-propinoxypipridine acid fumarate. Arch. Intern. Pharma- codynamic 134, 306-327 (1961)
  5. De Carvalho, M.S., and Jacobs, R.S., Two-step inactivation of bee venom phospholipase $A_2$ by Scalaradial. Biochem. Pharmacol. 42, 1621-1626 (1991) https://doi.org/10.1016/0006-2952(91)90432-5
  6. De Pasquale, R, Circosta, C., Occhiuto, F., De Rosa, S., and De Stefano, S., Pharmacological studies on terpenoids from marine sponges: analgesic and muscle relaxant effects. Phytother. Res. 5,49-53 (1991) https://doi.org/10.1002/ptr.2650050202
  7. De Rosa, S., De Giulio, A, and Iodice, C, Biological effects of prenylhydroquinones: Structure activity relationships studies on antimicrobial, brine shrimp and fish lethality assays. J. Nat. Prod. 57, 1711-1716 (1994) https://doi.org/10.1021/np50114a015
  8. Ferrandiz, M.L, Saul, M.J., Bustos, G., Paya, M., Alcaraz, M.J., and De Rosa, B., Avarol and avarone, two new anti-inflammatory agents of marine origin. Eur. J. Pharmacol. 253,75-82 (1994) https://doi.org/10.1016/0014-2999(94)90759-5
  9. Gil, B., Jesus Saul, M., Carmen Terencio, M., De Giulio, A., De Rosa, S., Jose Alcaraz, M., and Paya, M., Effect of marine 2-polyprenyl-l,4-hydroquinones on phospholipase A, activity and some inflammatory responses. Eur. J. Pharmacol. 285,281-288 (1995) https://doi.org/10.1016/0014-2999(95)00419-L
  10. Jurna, I. and Brune, K, Central effect of the NSAI agent, indomethacin, ibuprofen, and diclofenac, determined in C fiber-evoked activity in single neurons of the rats thalamus. Pain 95, 289-90 (2002)
  11. Kapure, J.N. and Saxena, H.C., Mathematical Statistics, S Chand and Co Ltd., Ram Nagar, New Delhi (1972)
  12. Karber, G, Bietrag Zur Kollectiven behandlung pharmakologischem, Rainhen Versuche. Arch. Exp. Pathol. Pharmakol. 162,480-482 (1931) https://doi.org/10.1007/BF01863914
  13. Kilagawa, I. and Kobayash, M., Anti-tumor natural products isolated from marine organisms Ed by Gan To, K.R; 169, 1-8 (1989)
  14. Liener, I.E., Toxic constituents of plant food stuffs, 2nd Ed., Academic Press, New York, 1980, p. 286
  15. Marshall, L.A., Winkler, J.D., Griswold, D.E., Bolognese, B., Roshak, A, Sung, C.M., Webb, E.F., and Jacobs, R.S., Effects of scalaradial, a type II phospholipase $A_{2}$ inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation. J. Pharmacol. Exp. Ther. 268,709-717 (1994)
  16. Meng, L., Mohan, R, Kwok, B.H.B., Elofsson, M., Sin, N., and Crews, C.M., Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo anti-inflammatory activity. Pro. Matl. Acad. Sci. USA 96, 10403-8 (1999)
  17. Obukowics, M.G, Welsch, D.J., Salsgiver, W.J., Martin-Berger, C.L., Chinn, K.S., Duffin, K.L., Ras, A and Needleman, P., Novel, Selective 6 or 5 fatty acid desaturase inhibitors as anti-inflammatory agents in mice. J. Pharmacol. Exp. Thera. 287, 157-66 (1998)
  18. Paget, G.E. and Bames, J.M., in: Evaluation of drug activities, Pharmacometric, Vol., D.R. Laurence (eds.), Academic Press, London-New York,1964
  19. Pfeilschifter, J., Schalkwijk, C., Briner, V.A, and Van den Bosch, H., Cytokine-stimulated secretion of group II phospholipase $A_{2}$ by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured at glomerular cells. J. Clin. Invest. 92, 2516-2523 (1993) https://doi.org/10.1172/JCI116860
  20. Siham, M.E., Omar, M.A, Ayman, R.B.,Seham, E., and Mahmoud, S.A, Studies on the anti-inflammatory and anti-nociceptive effect of melatonin in rats. Pharmacological Research 46, 235-243 (2002) https://doi.org/10.1016/S1043-6618(02)00094-4
  21. Vadas, P. and Pruzanski, W., Biology of disease, Role of secretory phospholipases $A_{2}$ in the pathobiology of disease. Lab. Invest. 55, 391-404 (1986)
  22. Vinegar, R, Truax, J.F., and Selph, J.L., Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents. Eur. J. Pharmacol. 37, 23-30 (1976) https://doi.org/10.1016/0014-2999(76)90004-2
  23. Winter, G.A., Rislfy, E.A., and Nuss, G. W., Carrageenan induced edema in hind paw of the rat as an assay for anti-inflammatory drug. Proc. Soc. Exp. Bioi. Med. 111, 544-547 (1962)