Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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CNS Activities of the Aqueous Extract of Hydrilla verticillata in Mice

  • Pal, Dilipkumar (Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences) ;
  • Balasaheb, Nimse Satish (Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences) ;
  • Khatun, Samina (Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences) ;
  • Bandyopadhyay, Pranab Kumar (Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences)
  • Published : 2006.03.01
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Abstract

The aqueous extract of Hydrilla verticillata (AEHV) was tested for possible pharmacological effects on experimental animals. AEHV significantly potentiated the sleeping time of mice induced by standard hypnotics viz. pentobarbitone sodium, diazepam, and meprobamate in a dose dependent manner. AEHV showed significant analgesic properties as evidenced by the significant reduction in the number of writhes and stretches induced in mice by 1.2% acetic acid solution. It also potentiated analgesia induced by morphine and pethidine in mice. Pretreatment with AEHV caused significant protection against strychnine and leptazol-induced convulsions. The behavioral studies on mice indicate CNS depressant activity of the aqueous extract of H. verticillata.

Keywords

References

  1. Achliya, G.S., Wadodkar, S.G., and Dorle, A.K., Evaluation of CNS activity of Bramhi Ghrita. Indian J.Pharmacol., 37(1), 33-36 (2005) https://doi.org/10.4103/0253-7613.13853
  2. Araki, H., Inoue, M., and Katoh, T., Total synthesis and absolute configuration of otteliones A and B, novel and potent antitumour agents from a fresh water plant. Org. Lett, 5(21), 3903-3906 (2003) https://doi.org/10.1021/ol035443x
  3. Bigoniya, P. and Rana A.C., Psychopharmacological profile of hydro alcoholic extract of Euphorbia neriifolia leaves in mice and rats. Ind. J. Expt. Biol., 43(10), 859-862 (2005)
  4. Bolton, S., In: Gennaro, A. R., Editor, Remington: The Science and Practice of Pharmacy, Vol II, 19th edition, Mack Publishing Co, Easton, Pennsylvania. pp. 94-134 (1995)
  5. Chopra, R.N., Nayer, S.L., and Chopra, I.C., Glossary of Indian Medicinal Plants, Publication and Information Directorate, New Delhi, India. pp. 39 (1992)
  6. Dandiya, P.C. and Collumbine, H., Studies on Acorus culmus: pharmacological actions of essential oils. J. Pharmac. Exp. Ther.,125, 353-359 (1959)
  7. Easley, J.F. and Shirley, R.L., Nutrient elements for livestock in aquatic plants. Hyacinth Control J., 12, 82-85 (1974)
  8. Eddy, N.B. and Leimbach, B., Analgesic and antipyretic activities of Dalbergia sissoo leaves. J. Pharmacol. Exp. Ther., 107, 385-393 (1953)
  9. Gitto, R., Camso, R., Orlando, V., Quartarone, S., Barreca, M.L., Ferreri, G., Russo, E., De Sarro, G., and Chimirri, A., Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives. Il Farmaco., 59, 7-12 (2004) https://doi.org/10.1016/j.farmac.2003.10.003
  10. Gupta, M., Mazumder, U.K., and Bhawal, S.R., CNS activities of Vitex negundo Linn. in mice. Indian J Expt. Biol., 37,143-146 (1999)
  11. Gupta, M., Mazumder, U.K., and Chakrabarty, S., CNS activities of methanolic extract of Moringa oleifera root in mice. Fitoterapia., 70, 244-250 (1999) https://doi.org/10.1016/S0367-326X(99)00029-5
  12. Gupta, M., Mazumder, U.K., Pal, D.K., Bhattacharya, S., and Chakraborty S., Studies on brain biogenic amines in methanol extract of Cuscuta rejlexa Roxb. stem and Corchorus olitorius Linn. seed treated mice. Acta Pol. Pharm. Drug-Res., 60(3), 207-210 (2003)
  13. Kar, A., Pharmacognosy and Pharmacobiotechnology, New Age International (P) Limited, Publishers, New Delhi. pp. 211-249 (2003)
  14. Kokate, C.K., Purohit, A.P., and Gokhale S.B., Pharmacognosy, Nirali Prakashan, Pune, India. pp. 218 (2003)
  15. Litchfield, J.T. and Wilcoxon, F.A., Simplified method of evaluating dose effect experiments. J. Pharmacol. Exp. Ther., 96, 99-133 (1949)
  16. Mandal S.C., Dhara A.K., Ashok Kumar C.K., and Maity B.C., Neuropharmacological activity of Xanthium strumarium Linn. extract. J. Herbs, Spices & Medicinal Plants, 8(1), 69-77 (2001) https://doi.org/10.1300/J044v08n01_09
  17. Mandal S.C., Dhara A.K., and Maity B.C., Studies on psychopharmacological activities of Andrographis paniculata extract. Phytother. Res., 15, 253-256 (2001) https://doi.org/10.1002/ptr.704
  18. Mashelkar, R.A., Editor., The Wealth of India: A Dictionary in Indian Raw Material and Industrial Products, Vol 2B, Publication and Information Directorate, CSIR, New Delhi, India. pp. 174-176 (1998)
  19. Mazumder, U.K., Gupta, M., Pal, D.K., and Bhattacharya, S., CNS activities of the methanol extract of Cuscuta rejlexa Roxb. Carchorus olitorius L. in mice. Malaysian J. Pharm., 2(1), (2005) (in press)
  20. Mazumder, U.K., Gupta, M., and Rath, N., CNS activities of Cassia fistula in mice. Phytother. Res., 12, 520-522 (1998) https://doi.org/10.1002/(SICI)1099-1573(199811)12:7<520::AID-PTR345>3.0.CO;2-O
  21. Murugasan, T., Ghosh, L., Das, J., Pal, M., and Saha, B.P., CNS activities of Jussiaea suffruticosa Linn. extract in rats and mice. Pharm. Pharmacol. Commun., 5, 663-666 (1999) https://doi.org/10.1211/146080899128734334
  22. Murugesan, T., Saravanam, K.S., Lakshmi, S., Ramya, G., and Thenmozhi, K., Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn. extract. Phytomed., 8(6), 472-476 (2001) https://doi.org/10.1078/S0944-7113(04)70068-9
  23. Pal, D.K., Padhiary, A.K., Otta, M., Khatun, S., and Mandal, M., Studies on antibacterial activities of aqueous extract of Hydrilla vertic illata plant, XVI annual conference of the PSI, Pachim Medinipur, India. pp. 60 (2005)
  24. Pal, D.K. and Nimse, S.B., Screening of the antioxidant activity of Hydrilla verticillata plant, Asian J. Chem., 2006 (in press)
  25. Pal, D.K. and Nimse, S.B., Hydrilla verticillata-a common aquatic plant with uncommon uses, Nat. Prod. Rad., 2006 (in press)
  26. Pal, D. K., Panda, C., Sinhababu, S, Dutta, A, and Bhattacharya, S., Evaluation of psychopharmacological effects of petroleum ether extract of Cuscuta reflexa Roxb. stem in mice. Acta Pol. Pharm.-Drug Res., 60, 481-486 (2003)
  27. Pal, D.K. and Nandi, M., CNS activities of Celsia coromandeliane Vahl. in mice. Acta Pol. Pharm.-Drug Res., 62(5), 355-361(2005)
  28. Pal, D.K., Sahoo, M., and Mishra, A.K., Analgesic and anticonvulsant effects of saponin isolated from the stems of Opuntia vulgaris Mill. in mice. Eur Bull Drug Res., 13, 91-97 (2005)
  29. Rolland, A., Fleurentin, J., Lanhers, M. C., Misslin, R., and Mortier, F., Neurophysiological effects of an extract of Eschscholzia californica Cham. (papeveraceae). Phytother. Res., 15, 377-381 (2001) https://doi.org/10.1002/ptr.884
  30. Spencer, D.F. and Ksander, G.G., Phenolic acid content of vegetative propagules of potamogeton spp. And Hydrilla vertic illata. J. Aquqt. Plant Manage., 32, 71-73 (1994)
  31. Ulen, B. and Tonderski, K.S., Cold climate posphorus uptake by submerged aquatic plants in a sewage treatment free water surface wetland. J. Environ. Sci. Health A Tox. Hazard Subst. Environ. Eng., 40(6-7), 1177-1190 (2005) https://doi.org/10.1081/ESE-200055632
  32. Vedhanayaki, G., Shastri, G.V., and Kuruvilla, A., Analgesic activity of Piper longum Linn. root. Ind. J. Expt. Biol., 41(6), 649-651 (2003)