The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effects of Sigoungcheongpyetang and Tonggyutanggamibang on airway mucus secretion and trecheal smooth muscle contractility

자경청폐탕(紫梗淸肺湯) 및 통궁탕가미방(通窮湯加味方)이 기도점액분비 및 기관평활근 긴장도에 미치는 영향

  • Han, Jae-Kyung (Department of pediatrics, College of Oriental Medicine, Daejeon University) ;
  • Kim, Yun-Hee (Department of pediatrics, College of Oriental Medicine, Daejeon University) ;
  • Yun, Jae-Eun (Department of pediatrics, College of Oriental Medicine, Daejeon University)
  • 한재경 (대전대학교 한의과대학 소아과학 교실) ;
  • 김윤희 (대전대학교 한의과대학 소아과학 교실) ;
  • 윤재은 (대전대학교 한의과대학 소아과학 교실)
  • Published : 2006.04.30
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Abstract

Objective : To investigate the effectiveness of two oriental medical prescriptions named Sigoungcheongpyetang(SCPT) and Tonggyutanggamibang(TGT) for mucin release from cultured hamster tracheal surface epithelial(HTSE) cells. Method : Confluent HTSE cells were metabolically radiolabeled with $^{3}H-glucosamine$ for 24hrs and chased for 30 min in the presence of SCPT or TGT to assess the effect of each agent $^{3}H-mucin$ release. Possible cytotoxicities of each agent were assessed by measuring lactate dehy drogenase(LDH) release. Also, the effects of SCPT and TGT on contrectility of isolated tracheal smooth muscle were investigated. Results : (1) SCPT and TGT significantly increased mucin release from cultured HTSE cells, with significantly cytotoxicity ; SCPT did not affect contractility of isolated tracheal smooth muscle and TGT inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusion : We suggest that the effects of SCPT and TGT with their components should be further investigated and it is of great value to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.

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