The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Autonomic Neural Regulation of Sodium Transporters and Water Channels in Rat Submandibular Gland

  • Ryu, Sun-Yeol (Department of Oromaxillofacial Surgery, Chonnam National University Dental School) ;
  • Jung, Hyun (Department of Oromaxillofacial Surgery, Chonnam National University Dental School) ;
  • Kim, Ki-Yung (Department of Oromaxillofacial Surgery, Chonnam National University Dental School) ;
  • Kim, Mi-Won (Department of Pediatric Nursing, Chonnam National University School of Nursing) ;
  • Lee, Jong-Un (Department of Physiology, Chonnam National University Medical School)
  • Published : 2006.04.21
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Abstract

The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic or parasympathetic nerves to the submandibular gland. One week later, the expression of Na,K-ATPase, epithelial sodium channels (ENaC), and aquaporins (AQP) was examined in the denervated and contralateral glands. The sympathetic denervation slightly but significantly decreased the expression of ${\alpha}1$ subunit of Na,K-ATPase, whereas the parasympathetic denervation increased it. The expression of ${\alpha}$-subunit of ENaC was significantly increased in both the denervated and contralateral glands either by the sympathetic or parasympathetic denervation. The sympathetic denervation significantly increased the expression of AQP5 in both the denervated and contralateral glands, whereas the parasympathetic denervation decreased it. It is suggested that the autonomic nerves have a tonic effect on the regulation of sodium transporters and AQP water channels in the salivary gland.

Keywords

References

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