The Korean Journal of Physiology and Pharmacology

  • 제10권1호
  • /
  • Pages.13-17
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  • 2006
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
권호 표지

Changes of CA1 Excitability in Rats after Prenatal Methylazoxymethanol Treatment

  • Jang, Sung-Young (Departments of Dental Pharmacology, College of Medicine, Kyungpook National University) ;
  • Choi, In-Sun (Departments of Dental Pharmacology, College of Medicine, Kyungpook National University) ;
  • Cho, Jin-Hwa (Departments of Dental Pharmacology, College of Medicine, Kyungpook National University) ;
  • Jang, Il-Sung (Departments of Dental Pharmacology, College of Medicine, Kyungpook National University) ;
  • Lee, Maan-Gee (Departments of Pharmacology, College of Medicine, Kyungpook National University) ;
  • Choi, Byung-Ju (Departments of Dental Pharmacology, College of Medicine, Kyungpook National University)
  • 발행 : 2006.02.21
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초록

Experimentally induced cortical disorganization exhibits many anatomical features which are characteristic of cortical malformations in children with early-onset epilepsy. We used an immunocytochemical technique and extracellular field potential recordings from the dorsal hippocampus to determine whether the excitability of the CA1 pyramidal cells was enhanced in rats with exnerimentallv induced hippocampal dysplasia. Compared with control rats, the MAM-treated rats displayed a decrease of paired pulse inhibition. When $GABA_A$ receptor antagonists were blocked with $10{\mu}M$ bicuculline the amplitude of the second population spike of the MAM-treated of rats was similar to that of the first population spike, as was in the control rats. The MAM-treated rats had fewer somatostatin and parvalbumin-immunoreactive neurons than the control rats. These results suggest that the enhanced neuronal responsiveness of the in vivo recording of the CA1 in this animal model may involve a reduction of CA1 inhibition.

키워드

참고문헌

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