YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antidiabetic Activity of Ginsam in db/db Mouse

긴삼의 db/db 마우스에서 항당뇨 효과

  • 한은정 (경희대학교 약학대학 약물학.임상약학교실) ;
  • 박금주 (경희대학교 약학대학 약물학.임상약학교실) ;
  • 최윤숙 (경희대학교 약학대학 약물학.임상약학교실) ;
  • 한기철 (경희대학교 약학대학 약물학.임상약학교실) ;
  • 박종석 (경희대학교 약학대학 약물학.임상약학교실) ;
  • 이경희 ((주) 유유 중앙연구소) ;
  • 고성권 (세명대학교 한방식품영양학과) ;
  • 정성현 (경희대학교 약학대학 약물학.임상약학교실)
  • Published : 2006.10.01
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Abstract

Type 2 diabetes mellitus is a chronic and hard to control disease. In order to develop the therapeutic agent for type 2 DM, many researchers investigated natural products using an in vitro and in vivo assay. In this study, we tried to explore the anti-diabetic activity and mechanisms of ginsam, which is a vinegar-processed ginseng radix. The db/db mice were randomly divided into four groups. The diabetes control (DC) group was orally administrated with distilled water, ginseng radix (GR) or ginsam (GS) was administrated orally at a dose of 150 mg/kg, and the positive control group was orally injected with metformin (MET) at a dose of 300 mg/kg for 5 weeks in db/db mice and measured body weight and blood glucose level every week. All treatment groups decreased the plasma glucose levels compared with diabetic control and GS group significantly lowered the insulin resistance index. GS group also reduced the plasma lipid levels mainly due to reduce the lipogenesis and increase the lipolysis in the fat tissue. In addition, GS group increased the GLUT4 mRNA expression levels in the fat and muscle tissues by 10 fold probably due to increase a $PPAR_{-\gamma}$ mRNA expression in fat tissue. Taken together, GS showed the anti-hyperglycemic and anti-hyperlipidemic activities and those activities may ascribe to over-expression of GLUT4 mRNA level and decrease the lipogenesis in fat tissue.

Keywords

References

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