YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Chronic Ethanol Consumption and Herbal Extracts Administration on the Antioxidant System and Ethanol Oxidation System in Rats

만성적인 에탄올 섭취와 천연물 투여가 흰쥐의 항산화계와 에탄올 산화계에 미치는 영향

  • Kim, Mok-Kyung (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Hyun, Sun-Hee (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Choung, Se-Young (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University)
  • 김목경 (경희대학교 약학대학 위생화학교실) ;
  • 현선희 (경희대학교 약학대학 위생화학교실) ;
  • 정세영 (경희대학교 약학대학 위생화학교실)
  • Published : 2006.08.31
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Abstract

This study had been done for the investigation of the effect of Vitis vinifera extract(V), Schisandra chinensis extract (S), Taraxacum officinale extract (T), Gardenia jasminoides extract (G), Angelica acutiloba extract (A) and Paeonia japonica extract (P), and their mixtures on the antioxidant and ethanol oxidation system which was induced by Lieber-DeCarli ethanol liquid diet. Male Sprague-Dawley rats were randomly divided into eight groups: ethanol diet (ED), normal diet (ND), ED+V (100 mg/kg/day), ED+S, ED+T, ED+G, ED+A and ED+P (300 mg/kg/day). We studied the effect on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) after herbal extracts administration for 6 weeks in rats induced by Lieber-DeCarli ethanol liquid diet. The differences in ADH and ALDH activity of the rats treated with herbal extracts and ED group were not significant. Phase I enzyme activity was found to be significantly higher in the ED+V than the ED group. Phase II enzymes (glutathione-S-transferase, phenol sulfatransferase) activities were found to be higher in the herbal extracts than the ED group. Herbal extracts not only reduced ethanol-induced elevation of level malondialdehyde but also protected against ethanol-induced decrease of reduced glutathione, gluthione reducatse, glutathione peroxidase, catalase and superoxide dismutase activities. Therefore, they can be utilized as a health functional food or new drug candidate for fatty liver and hepatotoxicity which was induced by chronic alcohol consumption.

Keywords

References

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