The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Hypolipemic Effect of 'Saengjinyanghyul-tang' water extracts in the Streptozotocin-induced Hyperlipemic SD Rat

생진양혈탕(生津養血湯) 물 추출물의 Streptozotocin 유발 고지혈증에 대한 효과

  • Hur, Hyun (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University) ;
  • Kim, Dae-Jun (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University) ;
  • Byun, Joon-Seok (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University) ;
  • Choi, Bin-Hye (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University)
  • 허현 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김대준 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 최빈혜 (대구한의대학교 한의과대학 비계내과학교실)
  • Published : 2006.06.30
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Abstract

In the Present study, the therapeutic hypolipemic effect of water extract of Saengjinyanghyl-tang (SJYHT), a herbal extract mixture for treatment of diabetes in oriental medicine was tested in Streptozotocin-induced diabetic hyperlipemic SD rats. For detect the therapeutic effects, the test articles were once a day dosed for 28 days by gastric gavage at a dosage 1000, 500 and 250mg/kg from 25 days after STZ-dosing, and the changes on body weight and gains, serum LDL, HDL, Triglyceride and Total Cholesterol levels were observed In addition, the effects of test articles were compared to that of Simvastatin, a well known hypolipemic agents 10mg/kg-dosing group. Base on these results, although no meaningful effects were detected on the serum HDL levels, it is concluded that Saengjinyanghyul-tang water extracts have relatively good favorable effect treatment of STZ-induced diabetic hyperlipemia because they showed clear evidences inhibit the increase of serum LDL, Triglyceride and Total Cholesterol levels. Therefore, it is expected that Saengjinyanghyul-tang extract has favorable potency to development hypolipemic drugs. In addition, about 1000mg/kg of Saengjinyanghyul-tang extracts have similar effect compared to that of Simvastatin 10mg/kg. The effective dosage of Saengjinyanghyul-tang water extracts in the present study was considered as below 250mg/kg.

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