대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제27권1호
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- Pages.102-113
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- 2006
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- 1226-9174(pISSN)
마황윤폐탕(麻黃潤肺湯) 추출물의 수컷 SD Rats에서 경구 단회투여 독성 평가
Single Dose Toxicity Test of Mahwangyounpae-tang Extract in Male SD Rats
- 조동희 (대구한의대학교 한의과대학 내과학교실) ;
- 박미연 (대구한의대학교 한의과대학 내과학교실) ;
- 최해윤 (대구한의대학교 한의과대학 내과학교실) ;
- 김종대 (대구한의대학교 한의과대학 내과학교실) ;
- 전귀옥 (대구한의대학교 한의과대학 내과학교실)
- Cho, Dong-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
- Park, Mee-Yeon (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
- Choi, Hae-Yun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
- Kim, Jong-Dae (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
- Jeon, Kwi-Ok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
- 발행 : 2006.03.30
초록
Objectives & Methods : To obtain the 50% lethal dose(LD50), approximated lethal dose(ALD) and approximated target organs of 'Mahwangyounpae-tang' for further study into such things as repeated dose toxicity, genotoxicity and reproductive toxicity, single dose toxicity was tested in male SD rats according to KFDA Guideline 1999-61[KFDA, 1999] at dosage levels of 2,000, 1,000, 500, 250 and 125 mg/kg/