Journal of Acupuncture Research
- 제23권3호
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- Pages.117-127
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- 2006
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
봉약침액(蜂藥鍼液)이 Scopolamine으로 기억장애(記憶障碍) 유발(誘發) 시 Acetylcholine Esterase 활성에 미치는 영향(影響)
The Effect of Bee Venom on Acetylcholine Esterase Activity during Scopolamine Induced Memorial Impairment
- Song, Jeong-Yeol (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyungwon University) ;
- Song, Ho-Sueb (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyungwon University)
- 발행 : 2006.06.20
초록
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease associated with aging in the human population. This disease is characterized by the following 4 structural changes : Atrophy of the Cortex, Parasympathetic, and other neural cells, the existence of Neurofibrillary tangles (NFTs), and the accumulation of Senile plaques. NFTs and Senile plaques is known to be the index of this disease. Senile plaques disturbs the neutro transmission and depletes of Acetylcholine. So, Recovery of Acetylcholine is the primal objective for treating Alzheimer's disease. So, Inhibiting the activity of Acetylcholine Esterase (AChE), which causes the hydrolysus of acetylcholine into choline and acetate, can be seen as a key role for treating Alzheimer's disease. Increasing body of evidence has been demonstrated that Bee Venom Acupuncture (BV) could compete with complex protein involving in multiple step of