대한예방한의학회지 (Journal of Society of Preventive Korean Medicine)

대한예방한의학회 (Society of Preventive Korean Medicine)
권호 표지

황기(黃芪) 투여시기가 Cyclophosphamide 유발 흰쥐의 백혈구감소증에 미치는 영향

The Effects of Astragali Radix on Cyclophosphamide-induced Leucopenia

  • 장재민 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 신용철 (경희대학교 한의과대학 예방의학교실)
  • Chang, Jae-Min (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee Univ.) ;
  • Ko, Seong-Gyu (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee Univ.) ;
  • Shin, Yong-Cheol (Dept. of Preventive Medicine, College of Oriental Medicine, Kyung Hee Univ.)
  • 발행 : 2006.06.30
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초록

In order to indentify the effect of Astragali Radix(A.R) on cyclophosphamide(C.Y) induced leukopenia, A.R. extracts(EAR) were treated to mice orally, and blood sampling was done by periods. For the in vivo experiments, mice were divided into 4 groups, which treated EAR before, or after C.Y injection, or both, or none. Rapid normalization in the peripheral blood count of WBC, neutrophils, lymphocytes, RBC, and platelets observed in every EAR treated group regardless of the treatment periods of EAR. These studies suggest that, A.R. premedication can be effective in protection of bone marrow suppression during anticancer therapy.

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