The Korea Journal of Herbology (대한본초학회지)
- Volume 21 Issue 2
- /
- Pages.189-195
- /
- 2006
- /
- 1229-1765(pISSN)
- /
- 2288-7199(eISSN)
Anti-inflammatory effect of extract of Asarum sieboldii in LPS-stimulated Murine peritoneal macrophage
LPS로 활성화된 복강 대식세포에서 세신 추출물의 항염증 효과
-
Jung, Won-Seok
(Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Yoo, Hyeon-Mi (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Seo, Sang-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Cho, Joon-Ki (Dept. of Internal Medicine, IKsan Oriental Hospital) ;
- Son, Ji-Woo (Dept. of Internal Medicine, IKsan Oriental Hospital) ;
-
Park, Min-Cheol
(Dept. of Internal Medicine, IKsan Oriental Hospital) ;
-
Choi, Chang-Min
(Dept. of Internal Medicine, Kwangju Oriental Hospital) ;
- Yeom, Seung-Ryong (Dept. of Internal Medicine, Kwangju Oriental Hospital) ;
- Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Chae, Young-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Kim, Yeong-Mok (Dept. of Oriental Pathology, College of Oriental Medicine, Wonkwang University) ;
-
Park, Sung-Joo
(Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
-
Song, Ho-Joon
(Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
-
정원석
(원광대학교 한의과대학 본초학 교실) ;
- 유현미 (원광대학교 한의과대학 본초학 교실) ;
- 서상완 (원광대학교 한의과대학 본초학 교실) ;
- 조준기 (원광대학교 익산 한방병원) ;
- 손지우 (원광대학교 익산 한방병원) ;
-
박민철
(원광대학교 익산 한방병원) ;
-
최창민
(원광대학교 광주 한방병원) ;
- 염승룡 (원광대학교 광주 한방병원) ;
- 황상욱 (원광대학교 한의과대학 본초학 교실) ;
- 김영우 (원광대학교 한의과대학 본초학 교실) ;
- 송달수 (원광대학교 한의과대학 본초학 교실) ;
- 채영석 (원광대학교 한의과대학 본초학 교실) ;
- 김영목 (원광대학교 한의과대학 병리학 교실) ;
-
박성주
(원광대학교 한의과대학 본초학 교실) ;
- 신민교 (원광대학교 한의과대학 본초학 교실) ;
-
송호준
(원광대학교 한의과대학 본초학 교실)
- Published : 2006.06.30
Abstract
Objectives : The purpose of this study was to investigate the anti-inflammatory effects of extract Asarum sieboldii(AS) on the peritoneal macrophage. Methods : To evaluate of anti-inflammatory of AS, we examined cytokines production in lipopolysacchride (LPS)-induced macrophages. Furthermore, we checked molecular mechanism using western blot. Results : 1. Extract from AS reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2. Extract from AS itself does not have any cytotoxic effect. AS inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase B a (IkBa) in the LPS-stimulated peritoneal macrophages Conclusion : AS down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of AS