The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibition of Cellular Proliferation by CURCUMAE LONGAE Rhizoma Extracts on MCF-7

강황(薑黃) 추출물이 유방암 세포주 MCF-7 증식 억제에 미치는 영향

  • Jung, Sun (College of Korean Medicine, Dongshin University) ;
  • Kim, Hyung-Woo (College of Korean Medicine, Dongshin University) ;
  • Park, Ji-Eun (College of Korean Medicine, Dong-Eui University) ;
  • Kim, Young-Gyun (College of Korean Medicine, Dong-Eui University) ;
  • Cho, Su-In (College of Korean Medicine, Dongshin University)
  • 정선 (동신대학교 한의과대학 본초학교실) ;
  • 김형우 (동신대학교 한의과대학 본초학교실) ;
  • 박지은 (동의대학교 한의과대학 내과학교실) ;
  • 김영균 (동의대학교 한의과대학 내과학교실) ;
  • 조수인 (동신대학교 한의과대학 본초학교실)
  • Published : 2006.03.30
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Abstract

Objectives : This investigation was undertaken to evaluate the anti-proliferation of CURCUMAE LONGAE Rhizoma extracts using MCF-7, human breast cancer cells. Methods : MCF-7 cells were cultured in Dulbecco's modified Eagle's medium/F12 supplemented with 10% fetal bovine serum and antibiotics. At varying times after extract treatment, cells were harvested with scraper and processed for analysis of proliferation, cytotoxicity. Results : The extract of CURCUMAE LONGAE Rhizoma strongly inhibits the proliferation of MCF-7 cells in a dose and time-dependent manner. Sulforhodamine B assay showed that the addition of ethanol extract of CURCUlVIAE LONGAE Rhizoma reduced the viability of MCF-7 cells in a dose-dependent manner. Conclusion : So, it can be concluded that CURCUMAE LONGAE Rhizoma have an inhibitive effect on MCF-7 human breast cancer cells.

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