Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-Inflammatory Effect of 'Jungcheonhwadamgangki-tang'in Xylene-Application Mouse Ear Acute Inflammation Model

정서화담강기탕(定瑞化痰降氣湯)이 Xylene으로 유발된 마우스의 급성 염증에 미치는 영향

  • Song, Muh-Sik (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Jeon, Kwi-Ok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Park, Mee-Yeon (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Choi, Hae-Yun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Jong-Dae (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Cho, Dong-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 송무식 (대구한의대학교 한의과대학 내과학교실) ;
  • 전귀옥 (대구한의대학교 한의과대학 내과학교실) ;
  • 박미연 (대구한의대학교 한의과대학 내과학교실) ;
  • 최해윤 (대구한의대학교 한의과대학 내과학교실) ;
  • 김종대 (대구한의대학교 한의과대학 내과학교실) ;
  • 조동희 (대구한의대학교 한의과대학 내과학교실)
  • Published : 2006.08.25
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Abstract

In the present study, the anti-inflammatory effect of 'Jungcheonhwadamgangki -tang' water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on body weight and ear weights and histopathological observation of induced ear were conducted with ear histomorphometry. The increases of absolute and relative ear weight detected in vehicle control compared to that of sham , were significantly and dose-dependently inhibited by Jungcheonhwadarn -gangki-tang in the present study. A classic acute inflammatory histological changes such as subcutaneous edema, hypertrophy and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Jungcheonhwadam-gangki-tang. In addition, the increases of ear thickness half and thickness full detected in the vehicle control, were also dose-dependently decreased in the all Jungcheonhwadamgangki-tang-dosing groups. Base on these results, it is concluded that Jungcheonhwadamgangki-tang water extracts have clear anti-inflammatory effect on the acute inflammation, and about 500 mg/kg of Jungcheonhwadamgangki-tang water extracts have similar effect compared to that of Dicrofenac 15 mg/kg.

Keywords

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