Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Comparison of Nelumbinis Semen Extract with Hypericum Perforatum and Fluoxetine in Animal Model of Depression

연자육의 항우울 효과 및 프로티옴 분석을 통한 기전 연구

  • Lee, Jin-Woo (Department of Physiology, College of Oriental Medicine, KyungHee University) ;
  • Hong, Moo-Chang (Department of Physiology, College of Oriental Medicine, KyungHee University) ;
  • Shin, Min-Kyu (Department of Physiology, College of Oriental Medicine, KyungHee University) ;
  • Bae, Hyun-Su (Department of Physiology, College of Oriental Medicine, KyungHee University,Purimed R&D Institute)
  • 이진우 (경희대학교 한의과대학 생리학교실) ;
  • 홍무창 (경희대학교 한의과대학 생리학교실) ;
  • 신민규 (경희대학교 한의과대학 생리학교실) ;
  • 배현수 (경희대학교 한의과대학 생리학교실,퓨리메드(주) 기업부설연구소)
  • Published : 2006.08.25
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Abstract

Clinical evidence suggests that Nelumbinis Semen extracts have antidepressive properties and may offer an interesting alternative for the treatment of mood disorders. It was the aim of the present study to compare the effects of Nelumbinis Semen extracts with those of fluoxetine and hypericum perforatum extract in the rat forced swimming test (FST) and chronic mild stress (CMS), a model of depression. In the FST, p.o. administration of Nelumbinis Semen extracts (1 mg) induced a statistically significant reduction of immobility. The active behaviors in that test did not reflect decreased general activity because Nelumbinis Semen extracts failed to alter the locomotor activity of rats, measured in the open field test. Moreover Nelumbinis Semen extracts was superior to fluoxetine and hypericum perforatum extract in the incidence of sexual side-effects. These effects of Nelumbinis Semen extracts on the rat behavior is to be ascribed to increased Cytochrome c oxidase polypeptide Vla-liver, Mitogen-activated protein kinase 1 , Adenylosuccinate synthetase, and Aldehyde dehydrogenase in rat hippocampus.

Keywords

References

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