Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

Electroacupuncture suppresses epileptic EEG in experimental induced epileptic rats

흰쥐의 간질 소발작에 대한 전침자극의 억제

  • Kim, Yun-Jin (Dept. of Acupuncture, Second Medical College, Nanjing University of TCM,Biomedical Laboratory, School of Physics, Seoul National University) ;
  • Kim, Jay-hyo (Dept. of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University) ;
  • Ma, Cheng (Dept. of Acupuncture, Second Medical College, Nanjing University of TCM) ;
  • Shen, Mei-Hong (Dept. of Acupuncture, Second Medical College, Nanjing University of TCM) ;
  • Li, Zhong-Ren (Dept. of Acupuncture, Second Medical College, Nanjing University of TCM) ;
  • Sohn, In-Chul (Dept. of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
  • 김연진 (중국 남경중의약대학 제2림상의학원 침구학교연실,서울대학교 자연과학대학 물리학과 한의학물리실험실) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 마빙 (중국 남경중의약대학 제2림상의학원 침구학교연실) ;
  • 침매홍 (중국 남경중의약대학 제2림상의학원 침구학교연실) ;
  • 이충인 (중국 남경중의약대학 제2림상의학원 침구학교연실) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실)
  • Published : 2006.06.27
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Abstract

Objectives: We investigated the effect of electroacupuncture on epileptic rat model and its underlying mechanisms on suppression of the epilepsy. Methods: It was used pentylenetetrazol $(35{\sim}40\;mg/kg.\;i.p)$ induced epileptic rat model and square wave electrical stimulations (5 mA, 5, 40 or 80 Hz frequency) was applied to acupoints on 'Dazhui' and 'Taichong' for 30min. Results: Electroacupuncture suppressed spikes and slow waves of EEG due to the epileptic condition. Out of electroacupuncture, a high frequency of 80Hz had a better effect for suppress epileptic EEG wave. Conclusions: Electroacupuncture can markedly reduce the excitability of cerebral cortex and strengthen the inhibitory process, checking epilepsy wave. Some intrathalamic nuclei have a promoting or inhibiting effect on epileptic EEG wave. This experimental study we are proposed to Electro-acupuncture can suppression epileptic rat model and it's scientific mechanisms.

Keywords