Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
권호 표지
DOI QR코드

DOI QR Code

Solution-phase Synthesis and Preliminary Evaluation of 1,6,8-Trisubstituted Tetrahydro-2H-pyrazino[1,2-a]pyrimidin-4,7-dione Derivatives as a NF-kB Inhibitor

  • Kim, Jin-Woong (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Lee, Su-Chul (Hawon Pharm. Co.) ;
  • Park, Hyeong-Beom (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Jo, Nam-Hyun (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Yoo, Kyung-Ho (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Cho, Jung-Hyuck (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Medicinal Chemistry Research Center, Korea Institute of Science and Technology)
  • Published : 2006.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

References

  1. Kahn, M. Synlett. 1993, 11, 821
  2. Souers, A. J.; Virgilio, A. A.; Schürer, S. S.; Ellman, J. A.; Kogan, T. P.; Ankener, H. W.; Vanderslice, P. Bioorg. Med. Chem. Lett. 1998, 8, 2297 https://doi.org/10.1016/S0960-894X(98)00416-8
  3. Souers, A. J.; Virgilio, A. A.; Rosenquist, A.; Fenuik, J. A.; Ellman, A. J. Am. Chem. Soc. 1999, 121, 1817 https://doi.org/10.1021/ja983742p
  4. Masakatsu, E.; Lee, M. S.; Hiroshi, N.; Marcin, S.; Scott, L.; Kahn, M. J. Am. Chem. Soc. 1999, 121, 12204 https://doi.org/10.1021/ja992203x
  5. Masakatsu, E.; Lee, M. S.; Richard, Y. W.; Shea, J. P.; Marcin, S.; Scot, L.; Kahn, M. J. Med. Chem. 2002, 45, 1395 https://doi.org/10.1021/jm0155897
  6. Masakatsu, E.; Lee, M. S.; Stasiak, M.; Kahn, M. Tetrahedron Lett. 2001, 42, 1237 https://doi.org/10.1016/S0040-4039(00)02248-6
  7. Kee, K. S.; Jois, D. S. Current Pharmaceutical Design 2003, 9, 1209 https://doi.org/10.2174/1381612033454900
  8. Kim, J.-W.; Cho, J.-H.; Han, T. H.; Lee, J. B.; Oh, C.-H. Bull. Korean Chem. Soc. 2006, 27, 484 https://doi.org/10.5012/bkcs.2006.27.4.484
  9. Jeong, D.-W.; Yoo, M.-H.; Kim, T. S.; Kim, J.-H.; Kim, I. Y. J. Biol. Chem. 2002, 277, 17871 https://doi.org/10.1074/jbc.M200808200

Cited by

  1. Solution-Phase Synthesis and Preliminary Evaluation of 1,6,8-Trisubstituted Tetrahydro-2H-pyrazino[1,2-a]pyrimidin-4,7-dione Derivatives as a NF-kB Inhibitor. vol.38, pp.19, 2006, https://doi.org/10.1002/chin.200719150