Bulletin of the Korean Chemical Society

  • 제27권9호
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  • Pages.1371-1376
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  • 2006
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Biological Evaluation of 3-Amino-4-aryl-piperidine Derivatives as BACE 1 Inhibitors

  • Lim, Hee-Jong (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Jung, Myung-Hee (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • ChoiLee, Ihl-Young (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, Woo-Kyu (Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
  • 발행 : 2006.09.20
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초록

BACE 1 ($\beta$-secretase), a membrane bound aspartic protease, is a key enzyme in the process of amyloid precursor protein (APP) into A$\beta$ peptide which is considered to play a causative role in Alzheimers Disease (AD). Here, we reported the synthesis and inhibitory activity of optically active 3-amino-4-aryl-piperidines.

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