Bulletin of the Korean Chemical Society

  • 제27권8호
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  • Pages.1199-1202
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  • 2006
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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A Simple Spectrofluorimetric Method for Determination of Mefenamic Acid in Pharmaceutical Preparation and Urine

  • Tabrizi, Ahad Bavili (Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences)
  • 발행 : 2006.08.20
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초록

A simple, sensitive and rapid spectrofluorimetric method was developed for determination of mefenamic acid in pharmaceutical preparation and human urine. The procedure is based on the oxidation of mefenamic acid with cerium (IV) to produce cerium (III), and its fluorescence was monitored at 354 nm after excitation at 255 nm. The variables affecting oxidation of drug were studied and optimized. Under the experimental conditions used, the calibration graphs were linear over the range 0.03-1.5 mg $L^{-1}$. The limit of detection was 0.009 mg $L^{-1}$ and the relative standard deviation for 5 replicate determinations of mefenamic acid at 1.0 mg $L^{-1}$ concentration level was 1.72%. Good recoveries in the range of 102-107 and 102-109% were obtained for pharmaceutical preparation and human urine, respectively. The proposed method was applied to the determination of MF in one pharmaceutical preparation and human urine. The amounts of mefenamic acid found are very similar to those obtained by a standard method.

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참고문헌

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피인용 문헌

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  2. Simple, rapid and sensitive method for the determination of mefenamic acid in pharmaceutical preparations vol.69, pp.8, 2014, https://doi.org/10.1134/S106193481408005X
  3. Determination of Organothiophosphate Insecticides in Environmental Water Samples by a Very Simple and Sensitive Spectrofluorimetric Method vol.95, pp.4, 2015, https://doi.org/10.1007/s00128-015-1612-7
  4. Novel mefenamic acid PVC membrane sensor based on a new Cd Schiff's base complex containing a phenanthroline unit vol.7, pp.62, 2017, https://doi.org/10.1039/C7RA06821B
  5. Spectrofluorimetric Determination of the Hypertensive Drug Captopril Based on Its Oxidation with Cerium(IV) vol.56, pp.4, 2006, https://doi.org/10.1002/jccs.200900112
  6. Determination of Some Cephalosporins in Pharmaceutical Formulations by a Simple and Sensitive Spectrofluorimetric Method vol.22, pp.1, 2006, https://doi.org/10.15171/ps.2016.06
  7. A Very Simple and Sensitive Spectrofluorimetric Method Based on the Oxidation with Cerium (IV) for the Determination of Four Different Drugs in Their Pharmaceutical Formulations vol.23, pp.1, 2006, https://doi.org/10.15171/ps.2017.08
  8. Spectrofluorimetric Determination of Atenolol and Carvedilol in Pharmaceutical Preparations after Optimization of Parameters using Response Surface Methodology vol.25, pp.3, 2006, https://doi.org/10.15171/ps.2019.30
  9. Quantum Chemical Computations, Molecular Docking, Vibrational Spectroscopic Analysis, Non-Linear Optical Properties and DFT Calculation of 2-[(2,3-Dimethylphenyl)Amino]Benzoic Acid vol.41, pp.9, 2006, https://doi.org/10.1080/10406638.2019.1700138